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Expression of human Kallikrein 14 (KLK14) in breast cancer is associated with higher tumour grades and positive nodal status

FRITZSCHE, F ; GANSUKH, T ; STEPHAN, C ; DIETEL, M ; DIAMANDIS, E. P ; DAHL, E ; KRISTIANSEN, G ; BORGONO, C. A ; BURKHARDT, M ; PAHL, S ; MAYORDOMO, E ; WINZER, K.-J ; WEICHERT, W ; DENKERT, C ; JUNG, K

British journal of cancer, 2006-02, Vol.94 (4), p.540-547 [Periódico revisado por pares]

Basingstoke: Nature Publishing Group

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Título:
Expression of human Kallikrein 14 (KLK14) in breast cancer is associated with higher tumour grades and positive nodal status
Autor: FRITZSCHE, F ; GANSUKH, T ; STEPHAN, C ; DIETEL, M ; DIAMANDIS, E. P ; DAHL, E ; KRISTIANSEN, G ; BORGONO, C. A ; BURKHARDT, M ; PAHL, S ; MAYORDOMO, E ; WINZER, K.-J ; WEICHERT, W ; DENKERT, C ; JUNG, K
Assuntos: Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Biomarkers, Tumor - analysis ; Breast Neoplasms - genetics ; Breast Neoplasms - pathology ; Disease-Free Survival ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Immunohistochemistry ; Kallikreins - biosynthesis ; Kallikreins - physiology ; Lymphatic Metastasis ; Mammary gland diseases ; Medical sciences ; Middle Aged ; Molecular Diagnostics ; Neoplasm Staging ; Prognosis ; Reverse Transcriptase Polymerase Chain Reaction ; Tumors
É parte de: British journal of cancer, 2006-02, Vol.94 (4), p.540-547
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
These authors contributed equally.
Shared senior authorship.
Descrição: Human kallikrein 14 (KLK14) is a steroid hormone-regulated member of the tissue kallikrein family of serine proteases, for which a prognostic and diagnostic value in breast cancer has been suggested. To further characterise the value of KLK14 as a breast tumour marker, we have carefully analysed KLK14 expression in normal breast tissue and breast cancer both on the RNA level by real-time RT-PCR (n = 39), and on the protein level (n = 127) using a KLK14-specific antibody for immunohistochemistry. We correlated KLK14 protein expression data with available clinico-pathological parameters (mean follow-up time was 55 months) including patient prognosis. KLK14 RNA expression as quantified by real-time RT-PCR was significantly more abundant in breast tumours compared to normal breast tissue (P = 0.027), an issue that had not been clarified recently. Concordantly with the RNA data, cytoplasmic KLK14 protein expression was significantly higher in invasive breast carcinomas compared to normal breast tissues (P = 0.003). Furthermore, KLK14 protein expression was associated with higher tumour grade (P = 0.041) and positive nodal status (P = 0.045) but was not significantly associated with shortened disease-free or overall patient survival time in univariate analyses. We conclude that KLK14 is clearly overexpressed in breast cancer in comparison to normal breast tissues and is positively associated with conventional parameters of tumour aggressiveness, but due to a missing association with survival times, the use of KLK14 immunohistochemistry as a prognostic marker in breast cancer is questionable.
Editor: Basingstoke: Nature Publishing Group
Idioma: Inglês

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Expression of human Kallikrein 14 (KLK14) in breast cancer is associated with higher tumour grades and positive nodal status

FRITZSCHE, F ; GANSUKH, T ; STEPHAN, C ; DIETEL, M ; DIAMANDIS, E. P ; DAHL, E ; KRISTIANSEN, G ; BORGONO, C. A ; BURKHARDT, M ; PAHL, S ; MAYORDOMO, E ; WINZER, K.-J ; WEICHERT, W ; DENKERT, C ; JUNG, K

Basingstoke: Nature Publishing Group

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