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Circulating Myeloid‐Related Protein–8/14 is Related to Thromboxane‐Dependent Platelet Activation in Patients With Acute Coronary Syndrome, With and Without Ongoing Low‐Dose Aspirin Treatment

Santilli, Francesca ; Paloscia, Leonardo ; Liani, Rossella ; Di Nicola, Marta ; Di Marco, Massimo ; Lattanzio, Stefano ; La Barba, Sara ; Pascale, Silvia ; Mascellanti, Marco ; Davì, Giovanni

Journal of the American Heart Association, 2014-07, Vol.3 (4), p.n/a [Periódico revisado por pares]

England: Blackwell Publishing Ltd

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Título:
Circulating Myeloid‐Related Protein–8/14 is Related to Thromboxane‐Dependent Platelet Activation in Patients With Acute Coronary Syndrome, With and Without Ongoing Low‐Dose Aspirin Treatment
Autor: Santilli, Francesca ; Paloscia, Leonardo ; Liani, Rossella ; Di Nicola, Marta ; Di Marco, Massimo ; Lattanzio, Stefano ; La Barba, Sara ; Pascale, Silvia ; Mascellanti, Marco ; Davì, Giovanni
Assuntos: acute coronary syndrome ; Acute Coronary Syndrome - blood ; Acute Coronary Syndrome - drug therapy ; Aged ; aspirin ; Aspirin - therapeutic use ; Calgranulin A - blood ; Calgranulin B - blood ; Chronic Disease ; Dinoprost - analogs & derivatives ; Dinoprost - urine ; Female ; Humans ; Male ; Middle Aged ; Myocardial Ischemia - blood ; Myocardial Ischemia - drug therapy ; Original Research ; Platelet Activation ; Platelet Aggregation Inhibitors - therapeutic use ; platelets ; platelet‐derived factors ; thromboxane ; Thromboxane B2 - analogs & derivatives ; Thromboxane B2 - urine
É parte de: Journal of the American Heart Association, 2014-07, Vol.3 (4), p.n/a
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: Background Platelet activation is involved in acute coronary syndromes (ACS). Incomplete suppression by low‐dose aspirin treatment of thromboxane (TX) metabolite excretion (urinary 11‐dehydro‐TXB2) is predictive of vascular events in high‐risk patients. Myeloid‐related protein (MRP)‐8/14 is a heterodimer secreted on activation of platelets, monocytes, and neutrophils, regulating inflammation and predicting cardiovascular events. Among platelet transcripts, MRP‐14 has emerged as a powerful predictor of ACS. Methods and Results We enrolled 68 stable ischemic heart disease (IHD) and 63 ACS patients, undergoing coronary angiography, to evaluate whether MRP‐8/14 release in the circulation is related to TX‐dependent platelet activation in ACS and IHD patients and to residual TX biosynthesis in low‐dose aspirin–treated ACS patients. In ACS patients, plasma MRP‐8/14 and urinary 11‐dehydro‐TXB2 levels were linearly correlated (r=0.651, P<0.001) but significantly higher than those in IHD patients (P=0.012, P=0.044) only among subjects not receiving aspirin. In aspirin‐treated ACS patients, MRP‐8/14 and 11‐dehydro‐TXB2 were lower versus those not receiving aspirin (P<0.001) and still significantly correlated (r=0.528, P<0.001). Higher 11‐dehydro‐TXB2 significantly predicted higher MRP‐8/14 in both all ACS patients and ACS receiving aspirin (P<0.001, adj R2=0.463 and adj R2=0.497) after multivariable adjustment. Conversely, plasma MRP‐8/14 (P<0.001) and higher urinary 8‐iso‐prostaglandin F2α (P=0.050) levels were significant predictors of residual, on‐aspirin, TX biosynthesis in ACS (adjusted R2=0.384). Conclusions Circulating MRP‐8/14 is associated with TX‐dependent platelet activation in ACS, even during low‐dose aspirin treatment, suggesting a contribution of residual TX to MRP‐8/14 shedding, which may further amplify platelet activation. Circulating MRP‐8/14 may be a target to test different antiplatelet strategies in ACS.
Editor: England: Blackwell Publishing Ltd
Idioma: Inglês

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Circulating Myeloid‐Related Protein–8/14 is Related to Thromboxane‐Dependent Platelet Activation in Patients With Acute Coronary Syndrome, With and Without Ongoing Low‐Dose Aspirin Treatment

Santilli, Francesca ; Paloscia, Leonardo ; Liani, Rossella ; Di Nicola, Marta ; Di Marco, Massimo ; Lattanzio, Stefano ; La Barba, Sara ; Pascale, Silvia ; Mascellanti, Marco ; Davì, Giovanni

England: Blackwell Publishing Ltd

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