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Rapid Formation of a Preoligomeric Peptide-Metal-Peptide Complex Following Copper(II) Binding to Amyloid β Peptides

Pedersen, Jeppe T ; Teilum, Kaare ; Heegaard, Niels H.H ; Østergaard, Jesper ; Adolph, Hans-Werner ; Hemmingsen, Lars

Angewandte Chemie (International ed.), 2011-03, Vol.50 (11), p.2532-2535 [Periódico revisado por pares]

Weinheim: Wiley-VCH Verlag

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Título:
Rapid Formation of a Preoligomeric Peptide-Metal-Peptide Complex Following Copper(II) Binding to Amyloid β Peptides
Autor: Pedersen, Jeppe T ; Teilum, Kaare ; Heegaard, Niels H.H ; Østergaard, Jesper ; Adolph, Hans-Werner ; Hemmingsen, Lars
Assuntos: Alzheimer's disease ; Amyloid beta-Peptides - chemistry ; Amyloid beta-Peptides - metabolism ; amyloid β peptides ; copper ; Copper - chemistry ; Copper - metabolism ; Humans ; Kinetics ; Models, Molecular ; peptides ; Protein Binding ; Time Factors
É parte de: Angewandte Chemie (International ed.), 2011-03, Vol.50 (11), p.2532-2535
Notas: http://dx.doi.org/10.1002/anie.201006335
This work was supported by Statens Serum Institut and the Drug Research Academy at the Faculty of Pharmaceutical Sciences, The Villum Kann Rasmussen Foundation, and The Danish Research Council for Independent Research | Natural Sciences.
Drug Research Academy
Statens Serum Institut
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ArticleID:ANIE201006335
ObjectType-Article-1
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Descrição: CuII connects peptides: The mechanism of binding of CuII to amyloid β peptides (Aβ) implicated in Alzheimer's disease was elucidated by stopped‐flow spectroscopy, NMR relaxation, and simulation of the kinetics on the millisecond timescale. Two monomeric Cu–Aβ species and a dimeric Aβ–Cu–Aβ species were identified (see picture). Aberrant aggregation apparently occurs from the monomeric species.
Editor: Weinheim: Wiley-VCH Verlag
Idioma: Inglês

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Rapid Formation of a Preoligomeric Peptide-Metal-Peptide Complex Following Copper(II) Binding to Amyloid β Peptides

Pedersen, Jeppe T ; Teilum, Kaare ; Heegaard, Niels H.H ; Østergaard, Jesper ; Adolph, Hans-Werner ; Hemmingsen, Lars

Weinheim: Wiley-VCH Verlag

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