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Antimicrobial peptides

Zhang, Ling-juan ; Gallo, Richard L.

Current biology, 2016-01, Vol.26 (1), p.R14-R19 [Periódico revisado por pares]

England: Elsevier Ltd

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  • Título:
    Antimicrobial peptides
  • Autor: Zhang, Ling-juan ; Gallo, Richard L.
  • Assuntos: Animals ; Antimicrobial Cationic Peptides - immunology ; Humans ; Immunity, Innate - immunology ; Insecta - immunology ; Plants - immunology ; Plants - microbiology
  • É parte de: Current biology, 2016-01, Vol.26 (1), p.R14-R19
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: Antimicrobial peptides and proteins (AMPs) are a diverse class of naturally occurring molecules that are produced as a first line of defense by all multicellular organisms. These proteins can have broad activity to directly kill bacteria, yeasts, fungi, viruses and even cancer cells. Insects and plants primarily deploy AMPs as an antibiotic to protect against potential pathogenic microbes, but microbes also produce AMPs to defend their environmental niche. In higher eukaryotic organisms, AMPs can also be referred to as ‘host defense peptides’, emphasizing their additional immunomodulatory activities. These activities are diverse, specific to the type of AMP, and include a variety of cytokine and growth factor-like effects that are relevant to normal immune homeostasis. In some instances, the inappropriate expression of AMPs can also induce autoimmune diseases, thus further highlighting the importance of understanding these molecules and their complex activities. This Primer will provide an update of our current understanding of AMPs. Zhang and Gallo provide an update on our current understanding of antimicrobial peptides — a diverse class of naturally occurring molecules produced as a first line of defense by all multicellular organisms.
  • Editor: England: Elsevier Ltd
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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