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Current Parallel Solid-Phase Synthesis of Drug-like Oxadiazole and Thiadiazole Derivatives for Combinatorial Chemistry

Abdildinova, Aizhan ; Gong, Young-Dae

ACS combinatorial science, 2018-06, Vol.20 (6), p.309-329 [Periódico revisado por pares]

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Título:
Current Parallel Solid-Phase Synthesis of Drug-like Oxadiazole and Thiadiazole Derivatives for Combinatorial Chemistry
Autor: Abdildinova, Aizhan ; Gong, Young-Dae
Assuntos: Combinatorial Chemistry Techniques ; Cycloaddition Reaction ; Drug Design ; Molecular Structure ; Oxadiazoles - chemical synthesis ; Oxidation-Reduction ; Small Molecule Libraries - chemical synthesis ; Solid-Phase Synthesis Techniques - methods ; Thiadiazoles - chemical synthesis
É parte de: ACS combinatorial science, 2018-06, Vol.20 (6), p.309-329
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: Solid-phase organic synthesis is a powerful tool in the synthesis of small organic molecules and building of libraries of compounds for drug discovery. Heterocyclic compounds are important components of the drug discovery field as well and serve as a core for hundreds of marketed drugs. In particular, oxadiazole and thiadiazole cores are compounds of great interest due to their comprehensive biological activities and structural features. Therefore, a plethora of oxadiazole and thiadiazole synthesis methodologies have been reported to date, including solution and solid-phase synthesis methodologies. In this review, we concentrate on and summarize solid-phase synthetic approaches of the oxadiazole and thiadiazole derivatives.
Editor: United States: American Chemical Society
Idioma: Inglês

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