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Leukaemia Inhibitory Factor Induces Mitogenesis in Swiss 3T3 Cells and Selective Enhancement via a Variety of Signalling Events

Levy, Carolina Schere ; Sauane, Moira ; Rudland, Philip S. ; de Asua, Luis Jimenez

Biochemical and biophysical research communications, 1997-07, Vol.236 (3), p.814-818 [Periódico revisado por pares]

United States: Elsevier Inc

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Título:
Leukaemia Inhibitory Factor Induces Mitogenesis in Swiss 3T3 Cells and Selective Enhancement via a Variety of Signalling Events
Autor: Levy, Carolina Schere ; Sauane, Moira ; Rudland, Philip S. ; de Asua, Luis Jimenez
Assuntos: 3T3 Cells ; Alprostadil - pharmacology ; Animals ; Diacylglycerol Kinase ; Dinoprost - pharmacology ; DNA - biosynthesis ; Drug Synergism ; Enzyme Activation - drug effects ; Enzyme Inhibitors - pharmacology ; Growth Inhibitors - pharmacology ; Insulin - pharmacology ; Interleukin-6 ; Leukemia Inhibitory Factor ; Lymphokines - pharmacology ; Mice ; Mitosis ; Phosphotransferases (Alcohol Group Acceptor) - antagonists & inhibitors ; Protein Kinase C - metabolism ; Pyrimidinones - pharmacology ; Signal Transduction ; Tetradecanoylphorbol Acetate - pharmacology ; Thiazoles - pharmacology ; Transforming Growth Factor beta - pharmacology
É parte de: Biochemical and biophysical research communications, 1997-07, Vol.236 (3), p.814-818
Descrição: Leukaemia inhibitory factor (LIF) stimulates cellular DNA synthesis in confluent quiescent Swiss 3T3 cells. Insulin and prostaglandin E1(PGE1), which fail to stimulate DNA synthesis alone, potentiate this effect. Prostaglandin F2α(PGF2α), which is mitogenic in these cells, enhances the effect of LIF on DNA synthesis. TGFβ1increases the effect of PGF2αbut not that of LIF. R-59022, a diacylglycerol kinase inhibitor which increases protein kinase C (PKC) activity, enhances only the PGF2αresponse. 13-Tetradecanoyl-12-phorbolacetate-mediated PKC depletion prevents the action of PGF2αbut not that of LIF, nor the PGF2αpotentiation of LIF-stimulated DNA synthesis. 1-Oleoyl-2acetylglycerol, a PKC and tyrosine kinase (TK) activator which mimics some of the PGF2αeffects, enhances only LIF-induced DNA synthesis in cells possessing intact PKC activity. These results suggest that stimulation of DNA synthesis by LIF, as well as its enhancement by PGF2α, may occur via a signalling pathway independent of PKC activation.
Editor: United States: Elsevier Inc
Idioma: Inglês

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Leukaemia Inhibitory Factor Induces Mitogenesis in Swiss 3T3 Cells and Selective Enhancement via a Variety of Signalling Events

Levy, Carolina Schere ; Sauane, Moira ; Rudland, Philip S. ; de Asua, Luis Jimenez

United States: Elsevier Inc

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