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Cytotoxic effect of selected wild orchids on two different human cancer cell lines

Joshi, Pusp Raj ; Paudel, Mukti Ram ; Chand, Mukesh Babu ; Pradhan, Shreeti ; Pant, Krishna Kumar ; Joshi, Giri Prasad ; Bohara, Manoj ; Wagner, Sven H. ; Pant, Basant ; Pant, Bijaya

Heliyon, 2020-05, Vol.6 (5), p.e03991-e03991, Article e03991 [Periódico revisado por pares]

England: Elsevier Ltd

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  • Título:
    Cytotoxic effect of selected wild orchids on two different human cancer cell lines
  • Autor: Joshi, Pusp Raj ; Paudel, Mukti Ram ; Chand, Mukesh Babu ; Pradhan, Shreeti ; Pant, Krishna Kumar ; Joshi, Giri Prasad ; Bohara, Manoj ; Wagner, Sven H. ; Pant, Basant ; Pant, Bijaya
  • Assuntos: Bioactive compounds ; Bioactive plant product ; Biological sciences ; Botany ; GC-MS ; MTT assay ; Natural product ; Orchids ; Pharmaceutical science ; Plant biology
  • É parte de: Heliyon, 2020-05, Vol.6 (5), p.e03991-e03991, Article e03991
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: Majority of the orchid species are used in the traditional medicines for the treatment of several diseases. They are the sources of polysaccharides, phenanthrenes, bibenzyl derivatives, revesteral, stilbenoids and polyphenol compounds. This study explored the cytotoxic activity of seven wild orchid species and identification of medicinally active compounds. The extracts of orchid species were screened for cytotoxic effect on the human cervical cancer cells (HeLa) and human glioblastoma cells (U251) using an MTT assay. The medicinally active compounds of high cytotoxic extracts were identified by GC-MS resulting in many stilbenoids and phenolic derivatives. The extract of Dendrobium transparens (DTs) and Vanda cristata (VCw) showed high cytotoxic effect towards the HeLa and U251 cell lines (IC50 of DTs: 382.14 μg/ml and 75.84 μg/ml respectively and IC50 of VCw: 317.23 μg/ml and 163.66 μg/ml respectively). This study concludes that they could be used as cancer therapeutics. Plant biology; Bioactive plant product; Biological sciences; Botany; Natural product; Pharmaceutical science; Bioactive compounds; GC-MS; MTT assay; Orchids.
  • Editor: England: Elsevier Ltd
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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