Citrate
chemistry and biology for biomaterials design
ABCD PBi
Citrate
chemistry and biology for biomaterials design
Autor:
Ma, Chuying
;
Gerhard, Ethan
;
Lu, Di
;
Yang, Jian
Assuntos:
Antimicrobial
;
Biocompatible Materials - chemical synthesis
;
Biomimetic Materials - chemistry
;
Citric acid
;
Citric Acid - blood
;
Citric Acid - cerebrospinal fluid
;
Citric Acid - chemistry
;
Citric Acid - pharmacology
;
Click Chemistry
;
Elastomer
;
Humans
;
Metabolic regulation
;
Osteogenic differentiation
;
Polymers - chemical synthesis
;
Polymers - chemistry
;
Regenerative engineering
;
Tissue Engineering
É parte de:
Biomaterials, 2018-09, Vol.178, p.383-400
Notas:
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-2
Descrição:
Leveraging the multifunctional nature of
citrate
in chemistry and inspired by its important role in biological tissues, a class of highly versatile and functional
citrate
-based materials (CBBs) has been developed via facile and cost-effective polycondensation. CBBs exhibiting tunable mechanical properties and degradation rates, together with excellent biocompatibility and processability, have been successfully applied in vitro and in vivo for applications ranging from soft to hard tissue regeneration, as well as for nanomedicine designs. We summarize in the review, chemistry considerations for CBBs design to tune polymer properties and to introduce functionality with a focus on the most recent advances, biological functions of
citrate
in native tissues with the new notion of degradation products as cell modulator highlighted, and the applications of CBBs in wound healing, nanomedicine, orthopedic, cardiovascular, nerve and bladder tissue engineering. Given the expansive evidence for citrate's potential in biology and biomaterial science outlined in this review, it is expected that citrate based materials will continue to play an important role in regenerative engineering.
Editor:
Netherlands: Elsevier Ltd
Idioma:
Inglês