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Chemical Profiling, Bioactive Properties, and Anticancer and Antimicrobial Potential of Juglans regia L. Leaves

Żurek, Natalia ; Pycia, Karolina ; Pawłowska, Agata ; Potocki, Leszek ; Kapusta, Ireneusz Tomasz

Molecules (Basel, Switzerland), 2023-02, Vol.28 (4), p.1989 [Periódico revisado por pares]

Switzerland: MDPI AG

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Título:
Chemical Profiling, Bioactive Properties, and Anticancer and Antimicrobial Potential of Juglans regia L. Leaves
Autor: Żurek, Natalia ; Pycia, Karolina ; Pawłowska, Agata ; Potocki, Leszek ; Kapusta, Ireneusz Tomasz
Assuntos: Alzheimer's disease ; Anti-Bacterial Agents - analysis ; Anti-Infective Agents - analysis ; Antibacterial activity ; anticancer activity ; Anticancer properties ; Antimicrobial agents ; antioxidant activity ; Antioxidants ; Antioxidants - chemistry ; Antitumor activity ; Biological activity ; By products ; Caco-2 Cells ; Cancer ; Cell lines ; Cosmetics ; Cosmetics industry ; Cytotoxicity ; Flavonoids ; Food ; Free radicals ; Functional foods & nutraceuticals ; Fungicides ; Humans ; Juglans - chemistry ; Juglans regia ; leaves ; Morphology ; Phenolic compounds ; Phenols ; Phenols - analysis ; Plant Extracts - chemistry ; Plant Leaves - chemistry ; polyphenol compounds ; Polyphenols ; Quercetin ; Quercetin - analysis ; Staphylococcus aureus ; Tandem Mass Spectrometry
É parte de: Molecules (Basel, Switzerland), 2023-02, Vol.28 (4), p.1989
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: The aim of this study was to assess the biological potential of the polyphenolic fraction isolated from leaves, collected in the Subcarpathian region (Poland). The phenolic profile was determined using the UPLC-PDA-MS/MS method. Biological activity was determined by evaluating the antioxidant, anticancer, antibacterial, and antifungal effects. Prior to this study, the purified polyphenolic fraction was not been tested in this regard. A total of 40 phenolic compounds (104.28 mg/g dw) were identified, with quercetin 3- -glucoside and quercetin pentosides dominating. The preparation was characterized by a high ability to chelate iron ions and capture O and OH radicals (reaching IC values of 388.61, 67.78 and 193.29 µg/mL, respectively). As for the anticancer activity, among the six tested cell lines, the preparation reduced the viability of the DLD-1, Caco-2, and MCF-7 lines the most, while in the antibacterial activity, among the seven tested strains, the highest susceptibility has been demonstrated against , and . Depending on the needs, such a preparation can be widely used in the design of functional food and/or the cosmetics industry.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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Chemical Profiling, Bioactive Properties, and Anticancer and Antimicrobial Potential of Juglans regia L. Leaves

Żurek, Natalia ; Pycia, Karolina ; Pawłowska, Agata ; Potocki, Leszek ; Kapusta, Ireneusz Tomasz

Switzerland: MDPI AG

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