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Vagus nerve stimulation activates two distinct neuroimmune circuits converging in the spleen to protect mice from kidney injury

Tanaka, Shinji ; Abe, Chikara ; Abbott, Stephen B G ; Zheng, Shuqiu ; Yamaoka, Yusuke ; Lipsey, Jonathan E ; Skrypnyk, Nataliya I ; Yao, Junlan ; Inoue, Tsuyoshi ; Nash, William T ; Stornetta, Daniel S ; Rosin, Diane L ; Stornetta, Ruth L ; Guyenet, Patrice G ; Okusa, Mark D

Proceedings of the National Academy of Sciences - PNAS, 2021-03, Vol.118 (12), p.1 [Periódico revisado por pares]

United States: National Academy of Sciences

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Título:
Vagus nerve stimulation activates two distinct neuroimmune circuits converging in the spleen to protect mice from kidney injury
Autor: Tanaka, Shinji ; Abe, Chikara ; Abbott, Stephen B G ; Zheng, Shuqiu ; Yamaoka, Yusuke ; Lipsey, Jonathan E ; Skrypnyk, Nataliya I ; Yao, Junlan ; Inoue, Tsuyoshi ; Nash, William T ; Stornetta, Daniel S ; Rosin, Diane L ; Stornetta, Ruth L ; Guyenet, Patrice G ; Okusa, Mark D
Assuntos: Acute Kidney Injury - etiology ; Acute Kidney Injury - metabolism ; Acute Kidney Injury - pathology ; Animals ; Biological Sciences ; Disease Susceptibility ; Health aspects ; Kidney diseases ; Mice ; Neural stimulation ; Neuroimmunomodulation ; Neurons ; Patient outcomes ; Prevention ; Spleen - immunology ; Spleen - innervation ; Sympathetic Nervous System - physiology ; Vagus nerve ; Vagus Nerve Stimulation
É parte de: Proceedings of the National Academy of Sciences - PNAS, 2021-03, Vol.118 (12), p.1
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Edited by Lawrence Steinman, Stanford University School of Medicine, Stanford, CA, and approved February 8, 2021 (received for review October 19, 2020)
Author contributions: S.T., C.A., S.B.G.A., D.L.R., R.L.S., P.G.G., and M.D.O. designed research; S.T., C.A., S.B.G.A., S.Z., Y.Y., J.E.L., N.I.S., J.Y., T.I., D.S.S., and R.L.S. performed research; S.T., C.A., S.B.G.A., S.Z., Y.Y., J.E.L., N.I.S., J.Y., T.I., D.S.S., and R.L.S. analyzed data; and S.T., W.T.N., D.L.R., P.G.G., and M.D.O. wrote the paper.
Descrição: Acute kidney injury is highly prevalent and associated with high morbidity and mortality, and there are no approved drugs for its prevention and treatment. Vagus nerve stimulation (VNS) alleviates inflammatory diseases including kidney disease; however, neural circuits involved in VNS-induced tissue protection remain poorly understood. The vagus nerve, a heterogeneous group of neural fibers, innervates numerous organs. VNS broadly stimulates these fibers without specificity. We used optogenetics to selectively stimulate vagus efferent or afferent fibers. Anterograde efferent fiber stimulation or anterograde (centripetal) sensory afferent fiber stimulation both conferred kidney protection from ischemia-reperfusion injury. We identified the C1 neurons-sympathetic nervous system-splenic nerve-spleen-kidney axis as the downstream pathway of vagus afferent fiber stimulation. Our study provides a map of the neural circuits important for kidney protection induced by VNS, which is critical for the safe and effective clinical application of VNS for protection from acute kidney injury.
Editor: United States: National Academy of Sciences
Idioma: Inglês

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Vagus nerve stimulation activates two distinct neuroimmune circuits converging in the spleen to protect mice from kidney injury

Tanaka, Shinji ; Abe, Chikara ; Abbott, Stephen B G ; Zheng, Shuqiu ; Yamaoka, Yusuke ; Lipsey, Jonathan E ; Skrypnyk, Nataliya I ; Yao, Junlan ; Inoue, Tsuyoshi ; Nash, William T ; Stornetta, Daniel S ; Rosin, Diane L ; Stornetta, Ruth L ; Guyenet, Patrice G ; Okusa, Mark D

United States: National Academy of Sciences

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