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Clinical characteristics of COVID-19-infected cancer patients: a retrospective case study in three hospitals within Wuhan, China

Zhang, L. ; Zhu, F. ; Xie, L. ; Wang, C. ; Wang, J. ; Chen, R. ; Jia, P. ; Guan, H.Q. ; Peng, L. ; Chen, Y. ; Peng, P. ; Zhang, P. ; Chu, Q. ; Shen, Q. ; Wang, Y. ; Xu, S.Y. ; Zhao, J.P. ; Zhou, M.

Annals of oncology, 2020-07, Vol.31 (7), p.894-901 [Periódico revisado por pares]

England: Elsevier Ltd

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  • Título:
    Clinical characteristics of COVID-19-infected cancer patients: a retrospective case study in three hospitals within Wuhan, China
  • Autor: Zhang, L. ; Zhu, F. ; Xie, L. ; Wang, C. ; Wang, J. ; Chen, R. ; Jia, P. ; Guan, H.Q. ; Peng, L. ; Chen, Y. ; Peng, P. ; Zhang, P. ; Chu, Q. ; Shen, Q. ; Wang, Y. ; Xu, S.Y. ; Zhao, J.P. ; Zhou, M.
  • Assuntos: Aged ; Betacoronavirus ; cancer ; China - epidemiology ; Cohort Studies ; Coronavirus Infections - diagnostic imaging ; Coronavirus Infections - epidemiology ; Coronavirus Infections - therapy ; COVID-19 ; Female ; Hospitalization - trends ; Humans ; Male ; Middle Aged ; Neoplasms - diagnostic imaging ; Neoplasms - epidemiology ; Neoplasms - therapy ; Original ; Pandemics ; Pneumonia, Viral - diagnostic imaging ; Pneumonia, Viral - epidemiology ; Pneumonia, Viral - therapy ; retrospective case study ; Retrospective Studies ; SARS-CoV-2 ; severe clinical events
  • É parte de: Annals of oncology, 2020-07, Vol.31 (7), p.894-901
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    Contributed equally.
  • Descrição: Cancer patients are regarded as a highly vulnerable group in the current Coronavirus Disease 2019 (COVID-19) pandemic. To date, the clinical characteristics of COVID-19-infected cancer patients remain largely unknown. In this retrospective cohort study, we included cancer patients with laboratory-confirmed COVID-19 from three designated hospitals in Wuhan, China. Clinical data were collected from medical records from 13 January 2020 to 26 February 2020. Univariate and multivariate analyses were carried out to assess the risk factors associated with severe events defined as a condition requiring admission to an intensive care unit, the use of mechanical ventilation, or death. A total of 28 COVID-19-infected cancer patients were included; 17 (60.7%) patients were male. Median (interquartile range) age was 65.0 (56.0–70.0) years. Lung cancer was the most frequent cancer type (n = 7; 25.0%). Eight (28.6%) patients were suspected to have hospital-associated transmission. The following clinical features were shown in our cohort: fever (n = 23, 82.1%), dry cough (n = 22, 81%), and dyspnoea (n = 14, 50.0%), along with lymphopaenia (n = 23, 82.1%), high level of high-sensitivity C-reactive protein (n = 23, 82.1%), anaemia (n = 21, 75.0%), and hypoproteinaemia (n = 25, 89.3%). The common chest computed tomography (CT) findings were ground-glass opacity (n = 21, 75.0%) and patchy consolidation (n = 13, 46.3%). A total of 15 (53.6%) patients had severe events and the mortality rate was 28.6%. If the last antitumour treatment was within 14 days, it significantly increased the risk of developing severe events [hazard ratio (HR) = 4.079, 95% confidence interval (CI) 1.086–15.322, P = 0.037]. Furthermore, patchy consolidation on CT on admission was associated with a higher risk of developing severe events (HR = 5.438, 95% CI 1.498–19.748, P = 0.010). Cancer patients show deteriorating conditions and poor outcomes from the COVID-19 infection. It is recommended that cancer patients receiving antitumour treatments should have vigorous screening for COVID-19 infection and should avoid treatments causing immunosuppression or have their dosages decreased in case of COVID-19 coinfection. •We retrospectively studied clinical features of 28 severe Coronavirus Disease 2019 (COVID-19)-infected cancer patients from three hospitals in Wuhan, China.•We analysed risk factors associated with occurrence of admission to an intensive care unit, usage of mechanical ventilation, or death.•COVID-19-infected cancer patients presented poor outcomes with high occurrence of clinically severe event and mortality.•Antitumour treatment within 14 days of COVID-19 diagnosis increased the risk of developing severe events.
  • Editor: England: Elsevier Ltd
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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