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Spatial control of rabies on heterogeneous landscapes

Russell, Colin A ; Real, Leslie A ; Smith, David L Baylis, Matthew

PloS one, 2006-12, Vol.1 (1), p.e27-e27 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Spatial control of rabies on heterogeneous landscapes
Autor: Russell, Colin A ; Real, Leslie A ; Smith, David L
Baylis, Matthew
Assuntos: Administration, Oral ; Analysis ; Animals ; Animals, Wild - virology ; Corridors ; Demographics ; Disease control ; Disease Outbreaks - prevention & control ; Disease Outbreaks - veterinary ; Disease Reservoirs - veterinary ; Disease Reservoirs - virology ; Dispersal ; Drug delivery systems ; Ecology ; Ecosystem ; Epidemics ; Herd immunity ; Immunity ; Immunization ; Infectious Diseases ; Mathematical analysis ; Mathematical models ; Models, Biological ; Oscillations ; Permeability ; Population Dynamics ; Procyon lotor ; Protection and preservation ; Public Health and Epidemiology ; Public Health and Epidemiology/Health Policy ; Rabies ; Rabies - epidemiology ; Rabies - prevention & control ; Rabies - veterinary ; Rabies Vaccines - administration & dosage ; Raccoons - virology ; Rivers ; Seasons ; Spatial distribution ; Terrestrial environments ; Vaccination ; Vaccines ; Wave dispersion ; Wildlife ; Wildlife conservation ; Wildlife habitats
É parte de: PloS one, 2006-12, Vol.1 (1), p.e27-e27
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Conceived and designed the experiments: CR DS. Performed the experiments: CR. Analyzed the data: LR CR DS. Contributed reagents/materials/analysis tools: CR DS. Wrote the paper: LR CR DS
Descrição: Rabies control in terrestrial wildlife reservoirs relies heavily on an oral rabies vaccine (ORV). In addition to direct ORV delivery to protect wildlife in natural habitats, vaccine corridors have been constructed to control the spread; these corridors are often developed around natural barriers, such as rivers, to enhance the effectiveness of vaccine deployment. However, the question of how to optimally deploy ORV around a river (or other natural barrier) to best exploit the barrier for rabies control has not been addressed using mathematical models. Given an advancing epidemic wave, should the vaccine be distributed on both sides of barrier, behind the barrier, or in front of it? Here, we introduce a new mathematical model for the dynamics of raccoon rabies on a spatially heterogeneous landscape that is both simple and realistic. We demonstrate that the vaccine should always be deployed behind a barrier to minimize the recurrence of subsequent epidemics. Although the oral rabies vaccine is sufficient to induce herd immunity inside the vaccinated area, it simultaneously creates a demographic refuge. When that refuge is in front of a natural barrier, seasonal dispersal from the vaccine corridor into an endemic region sustains epidemic oscillations of raccoon rabies. When the vaccine barrier creates a refuge behind the river, the low permeability of the barrier to host movement limits dispersal of the host population from the protected populations into the rabies endemic area and limits subsequent rabies epidemics.
Editor: United States: Public Library of Science
Idioma: Inglês

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Spatial control of rabies on heterogeneous landscapes

Russell, Colin A ; Real, Leslie A ; Smith, David L Baylis, Matthew

United States: Public Library of Science

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