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The Combination of Oolonghomobisflavan B and Diallyl Disulfide Induces Apoptotic Cell Death via 67-kDa Laminin Receptor/Cyclic Guanosine Monophosphate in Acute Myeloid Leukemia Cells

Bae, Jaehoon ; Park, Su-Jin

Current Issues in Molecular Biology, 2024-03, Vol.46 (3), p.2444-2455 [Periódico revisado por pares]

Switzerland: MDPI AG

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  • Título:
    The Combination of Oolonghomobisflavan B and Diallyl Disulfide Induces Apoptotic Cell Death via 67-kDa Laminin Receptor/Cyclic Guanosine Monophosphate in Acute Myeloid Leukemia Cells
  • Autor: Bae, Jaehoon ; Park, Su-Jin
  • Assuntos: acid sphingomyelinase ; acute myeloid leukemia ; Apoptosis ; Aprotinin ; Biochemistry ; Communication ; cyclic guanosine monophosphate ; diallyl disulfide ; Enzymes ; Ethylenediaminetetraacetic acid ; Laminin ; Nitric oxide ; oolonghomobisflavan B ; Protein kinases
  • É parte de: Current Issues in Molecular Biology, 2024-03, Vol.46 (3), p.2444-2455
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: Diallyl disulfide (DADS) is a well-known principal functional component derived from garlic ( ) that has various health benefits. Previously, we identified a 67-kDa laminin receptor, a receptor for oolong tea polyphenol oolonghomobisflavan B (OHBFB). However, its molecular mechanisms still remain to be elucidated. Here, we show that DADS synergistically enhanced the effect of the oolong tea polyphenol oolonghomobisflavan B (OHBFB), which induces apoptosis in acute myeloid leukemia (AML) cancer cells without affecting normal human peripheral blood mononuclear cells (PBMCs). The underlying mechanism of OHBFB-induced anti-AML effects involves the upregulation of the 67-kDa laminin receptor/endothelial nitric oxide synthase/cyclic guanosine monophosphate (cGMP)/protein kinase c delta (PKCδ)/acid sphingomyelinase (ASM)/cleaved caspase-3 signaling pathway. In conclusion, we show that the combination of OHBFB and DADS synergistically induced apoptotic cell death in AML cells through activation of 67LR/cGMP/PKCδ/ASM signaling pathway. Moreover, in this mechanism, we demonstrate DADS may reduce the enzyme activity of phosphodiesterase, which is a negative regulator of cGMP that potentiates OHBFB-induced AML apoptotic cell death without affecting normal PBMCs.
  • Editor: Switzerland: MDPI AG
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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