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Circulating folic acid in plasma: relation to folic acid fortification

Kalmbach, Renee D ; Choumenkovitch, Silvina F ; Troen, Aron M ; D'Agostino, Ralph ; Jacques, Paul F ; Selhub, Jacob

The American journal of clinical nutrition, 2008-09, Vol.88 (3), p.763-768 [Periódico revisado por pares]

Bethesda, MD: American Society for Nutrition

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Título:
Circulating folic acid in plasma: relation to folic acid fortification
Autor: Kalmbach, Renee D ; Choumenkovitch, Silvina F ; Troen, Aron M ; D'Agostino, Ralph ; Jacques, Paul F ; Selhub, Jacob
Assuntos: 5-methyltetrahydrofolate ; Adult ; Aged ; Aged, 80 and over ; Anatomy & physiology ; Biochemistry ; Biological and medical sciences ; blood circulation ; blood plasma ; blood sampling ; Cohort Studies ; cross-sectional studies ; Diet ; dietary exposure ; Feeding. Feeding behavior ; Female ; folic acid ; Folic Acid - administration & dosage ; Folic Acid - blood ; food fortification ; Food, Fortified ; fortified foods ; Framingham Offspring Cohort ; Fundamental and applied biological sciences. Psychology ; Heart Diseases - epidemiology ; Heart Diseases - prevention & control ; Humans ; Male ; Middle Aged ; Multicenter Studies as Topic ; New England ; Nutrition ; nutrition assessment ; nutritional status ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vitamin B
É parte de: The American journal of clinical nutrition, 2008-09, Vol.88 (3), p.763-768
Descrição: BACKGROUND: The implementation of folic acid fortification in the United States has resulted in unprecedented amounts of this synthetic form of folate in the American diet. Folic acid in circulation may be a useful measure of physiologic exposure to synthetic folic acid, and there is a potential for elevated concentrations after fortification and the possibility of adverse effects. OBJECTIVE: We assessed the effect of folic acid fortification on circulating concentrations of folic acid and 5-methyltetrahydrofolate in the Framingham Offspring Cohort. DESIGN: This is a cross-sectional study that used plasma samples from fasting subjects before and after fortification. Samples were measured for folate distribution with the use of an affinity-HPLC method with electrochemical detection. RESULTS: Among nonsupplement users, the median concentration of folic acid in plasma increased from 0.25 to 0.50 nmol/L (P < 0.001) after fortification, and among supplement users the median increased from 0.54 to 0.68 nmol/L (P = 0.001). Among nonsupplement users, the prevalence of high circulating folic acid (>=85th percentile) increased from 9.4% to 19.1% (P = 0.002) after fortification. Among supplement users, the prevalence of high circulating folic acid increased from 15.9% to 24.3% (P = 0.02). Folic acid intake and total plasma folate were positively and significantly related to high circulating folic acid after adjustment for potential confounding factors (P for trend < 0.001). CONCLUSIONS: Folic acid fortification has resulted in increased exposure to circulating folic acid. The biochemical and physiologic consequences of this are unknown, but these findings highlight the need to understand the effects of chronic exposure to circulating folic acid.
Editor: Bethesda, MD: American Society for Nutrition
Idioma: Inglês

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Circulating folic acid in plasma: relation to folic acid fortification

Kalmbach, Renee D ; Choumenkovitch, Silvina F ; Troen, Aron M ; D'Agostino, Ralph ; Jacques, Paul F ; Selhub, Jacob

Bethesda, MD: American Society for Nutrition

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