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Anabolic effects of leucine-rich whey protein, carbohydrate, and soy protein with and without β-hydroxy-β-methylbutyrate (HMB) during fasting-induced catabolism: A human randomized crossover trial

Rittig, Nikolaj ; Bach, Ermina ; Thomsen, Henrik H ; Møller, Andreas B ; Hansen, Jakob ; Johannsen, Mogens ; Jensen, Erik ; Serena, Anja ; Jørgensen, Jens O ; Richelsen, Bjørn ; Jessen, Niels ; Møller, Niels

Clinical nutrition (Edinburgh, Scotland), 2017-06, Vol.36 (3), p.697-705 [Periódico revisado por pares]

England: Elsevier Ltd

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Anabolic effects of leucine-rich whey protein, carbohydrate, and soy protein with and without β-hydroxy-β-methylbutyrate (HMB) during fasting-induced catabolism: A human randomized crossover trial
Autor: Rittig, Nikolaj ; Bach, Ermina ; Thomsen, Henrik H ; Møller, Andreas B ; Hansen, Jakob ; Johannsen, Mogens ; Jensen, Erik ; Serena, Anja ; Jørgensen, Jens O ; Richelsen, Bjørn ; Jessen, Niels ; Møller, Niels
Assuntos: Adaptor Proteins, Signal Transducing - genetics ; Adaptor Proteins, Signal Transducing - metabolism ; Adult ; Anabolic Agents - administration & dosage ; Body Mass Index ; Cross-Over Studies ; Dietary Carbohydrates - administration & dosage ; Fasting ; Gastroenterology and Hepatology ; Glucagon - blood ; HMB ; Humans ; Leucine ; Leucine - administration & dosage ; Male ; Muscle, Skeletal - drug effects ; Muscle, Skeletal - metabolism ; Phosphoproteins - genetics ; Phosphoproteins - metabolism ; Phosphorylation ; Protein ; Ribosomal Protein S6 Kinases, 90-kDa - genetics ; Ribosomal Protein S6 Kinases, 90-kDa - metabolism ; Signal Transduction ; Soy ; Soybean Proteins - administration & dosage ; TOR Serine-Threonine Kinases - genetics ; TOR Serine-Threonine Kinases - metabolism ; Valerates - administration & dosage ; Whey ; Whey Proteins - administration & dosage ; Young Adult
É parte de: Clinical nutrition (Edinburgh, Scotland), 2017-06, Vol.36 (3), p.697-705
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-News-1
ObjectType-Feature-3
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Descrição: Summary Background Protein-rich beverages are widely used clinically to preserve muscle protein and improve physical performance. Beverages with high contents of leucine or its keto-metabolite β-hydroxy-β-methylbutyrate (HMB) are especially anabolic in muscle, but it is uncertain whether this also applies to catabolic conditions such as fasting and whether common or separate intracellular signaling cascades are involved. Objective To compare a specific leucine-rich whey protein beverage (LWH) with isocaloric carbohydrate- (CHO), soy protein (SOY), and soy protein +3 g HMB (HMB) during fasting-induced catabolic conditions. Design Eight healthy lean male subjects underwent four interventions (LWH, CHO, SOY, and HMB) using a randomized crossover design. Each trial included a 36 h fast and consisted of a 3 h basal fasting period and a 4 h ‘sipping’ period. Results Forearm net balances of phenylalanine (NBphe , measure of net protein loss) improved for all groups (p < 0.05), but more prominently so for LWH and HMB compared with SOY (p < 0.05). Muscle protein phosphorylation of mammalian target of rapamycin (mTOR) and its downstream targets eukaryotic translation factor 4E-binding protein 1 (4EBP1) and ribosomal S6 kinase 1 (S6) were distinctly increased during LWH consumption (p < 0.05). The ratio between autophagy protein microtubule-associated protein 1 light chain-3β II and I (LC3II/LC3I, a measure of autophagy activity) was decreased during LWH and SOY intake compared with the fasting period (p < 0.05). Conclusion LWH and HMB have superior anabolic effects on muscle protein kinetics after 36 h of fasting, and LWH distinctly activates the mTOR pathway. These novel findings suggest that leucine-rich whey protein and/or HMB are specifically beneficial during fasting-induced catabolic conditions.
Editor: England: Elsevier Ltd
Idioma: Inglês

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Anabolic effects of leucine-rich whey protein, carbohydrate, and soy protein with and without β-hydroxy-β-methylbutyrate (HMB) during fasting-induced catabolism: A human randomized crossover trial

Rittig, Nikolaj ; Bach, Ermina ; Thomsen, Henrik H ; Møller, Andreas B ; Hansen, Jakob ; Johannsen, Mogens ; Jensen, Erik ; Serena, Anja ; Jørgensen, Jens O ; Richelsen, Bjørn ; Jessen, Niels ; Møller, Niels

England: Elsevier Ltd

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