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Characterization of bbtTICAM from amphioxus suggests the emergence of a MyD88-independent pathway in basal chordates

Yang, Manyi ; Yuan, Shaochun ; Huang, Shengfeng ; Li, Jun ; Xu, Liqun ; Huang, Huiqing ; Tao, Xin ; Peng, Jian ; Xu, Anlong

Cell research, 2011-10, Vol.21 (10), p.1410-1423 [Periódico revisado por pares]

England: Nature Publishing Group

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Characterization of bbtTICAM from amphioxus suggests the emergence of a MyD88-independent pathway in basal chordates
Autor: Yang, Manyi ; Yuan, Shaochun ; Huang, Shengfeng ; Li, Jun ; Xu, Liqun ; Huang, Huiqing ; Tao, Xin ; Peng, Jian ; Xu, Anlong
Assuntos: Adaptor Proteins, Signal Transducing - genetics ; Adaptor Proteins, Signal Transducing - metabolism ; Amino Acid Motifs ; Animals ; Branchiostoma lanceolatum ; Chordata ; Chordata, Nonvertebrate - genetics ; Chordata, Nonvertebrate - metabolism ; Humans ; Interferon Type I - biosynthesis ; Interferon Type I - genetics ; Myeloid Differentiation Factor 88 - genetics ; Myeloid Differentiation Factor 88 - metabolism ; NF-kappa B - genetics ; NF-kappa B - metabolism ; Original ; Protein Multimerization ; Sequence Homology, Amino Acid ; Signal Transduction - physiology ; Toll-Like Receptors - genetics ; Toll-Like Receptors - metabolism ; 公路运输 ; 基底 ; 文昌鱼 ; 相互作用 ; 脊椎动物 ; 脊索动物 ; 表征 ; 通路
É parte de: Cell research, 2011-10, Vol.21 (10), p.1410-1423
Notas: TLR; TICAM; MyD88-independent pathway; innate immunity; evolution
The MyD88-independent pathway, one of the two crucial TLR signaling routes, is thought to be a vertebrate innovation. However, a novel Toll/interleukin-1 receptor （TIR） adaptor, designated bbtTICAM, which was identified in the basal chordate amphioxus, links this pathway to invertebrates. The protein architecture of bbtTICAM is similar to that of vertebrate TICAM1 （TIR-containing adaptor molecule-I, also known as TRIF）, while phylogenetic analy- sis based on the TIR domain indicated that bbtTICAM is the oldest ortholog of vertebrate TICAM1 and TICAM2 （TIR-containing adaptor molecule-2, also known as TRAM）. Similar to human TICAM1, bbtTICAM activates NF-κB in a MyD88-independent manner by interacting with receptor interacting protein （RIP） via its RHIM motif. Such activation requires bbtTICAM to form homodimers in endosomes, and it may be negatively regulated by amphioxus SARM （sterile α and armadillo motif-containing protein） and TRAF2. However, bbtTICAM did not induce the pro- duction of type I interferon. Thus, our study not only presents the ancestral features of vertebrate TICAM1 and TI- CAM2, but also reveals the evolutionary origin of the MyD88-independent pathway from basal chordates, which will aid in understanding the development of the vertebrate TLR network.
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These two authors contributed equally to this work.
Descrição: The MyD88-independent pathway, one of the two crucial TLR signaling routes, is thought to be a vertebrate innovation. However, a novel Toll/interleukin-1 receptor （TIR） adaptor, designated bbtTICAM, which was identified in the basal chordate amphioxus, links this pathway to invertebrates. The protein architecture of bbtTICAM is similar to that of vertebrate TICAM1 （TIR-containing adaptor molecule-I, also known as TRIF）, while phylogenetic analy- sis based on the TIR domain indicated that bbtTICAM is the oldest ortholog of vertebrate TICAM1 and TICAM2 （TIR-containing adaptor molecule-2, also known as TRAM）. Similar to human TICAM1, bbtTICAM activates NF-κB in a MyD88-independent manner by interacting with receptor interacting protein （RIP） via its RHIM motif. Such activation requires bbtTICAM to form homodimers in endosomes, and it may be negatively regulated by amphioxus SARM （sterile α and armadillo motif-containing protein） and TRAF2. However, bbtTICAM did not induce the pro- duction of type I interferon. Thus, our study not only presents the ancestral features of vertebrate TICAM1 and TI- CAM2, but also reveals the evolutionary origin of the MyD88-independent pathway from basal chordates, which will aid in understanding the development of the vertebrate TLR network.
Editor: England: Nature Publishing Group
Idioma: Inglês

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Characterization of bbtTICAM from amphioxus suggests the emergence of a MyD88-independent pathway in basal chordates

Yang, Manyi ; Yuan, Shaochun ; Huang, Shengfeng ; Li, Jun ; Xu, Liqun ; Huang, Huiqing ; Tao, Xin ; Peng, Jian ; Xu, Anlong

England: Nature Publishing Group

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