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Endometriosis

Bulun, Serdar E

The New England journal of medicine, 2009-01, Vol.360 (3), p.268-279 [Periódico revisado por pares]

Waltham, MA: Massachusetts Medical Society

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Título:
Endometriosis
Autor: Bulun, Serdar E
Assuntos: Biological and medical sciences ; Development and progression ; DNA Methylation ; Endometriosis ; Endometriosis - genetics ; Endometriosis - metabolism ; Endometrium - metabolism ; Epigenesis, Genetic ; Estrogens - biosynthesis ; Female ; Female genital diseases ; Gene Expression Profiling ; General aspects ; Gynecology. Andrology. Obstetrics ; Health aspects ; Humans ; Infertility, Female - etiology ; Medical sciences ; Non tumoral diseases ; Ovarian Diseases - metabolism ; Peritoneal Diseases - metabolism ; Prostaglandins - biosynthesis ; Prostaglandins - physiology ; Women
É parte de: The New England journal of medicine, 2009-01, Vol.360 (3), p.268-279
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: This review emphasizes the participation of estrogen and inflammation in the development of endometriosis. A feedback cycle in which prostaglandins and aromatase activity are prominent allows for the persistence of endometriotic tissue. Knowledge of this cycle has important implications for the treatment of endometriosis. This review emphasizes the participation of estrogen and inflammation in the development of endometriosis. A feedback cycle in which prostaglandins and aromatase activity are prominent allows for the persistence of endometriotic tissue. Knowledge of this cycle has important implications for the treatment of endometriosis. Endometriosis is an estrogen-dependent inflammatory disease that affects 5 to 10% of women of reproductive age in the United States. 1 Its defining feature is the presence of endometrium-like tissue in sites outside the uterine cavity, primarily on the pelvic peritoneum and ovaries. The main clinical features are chronic pelvic pain, pain during intercourse, and infertility. 1 Endometriosis can be the result of diverse anatomical or biochemical aberrations of uterine function. For example, endometriosis commonly develops in young women with vaginal obstruction of outflow, possibly because of large quantities of backwashed menstrual tissue that has become implanted on pelvic organs. 2 In contrast, . . .
Editor: Waltham, MA: Massachusetts Medical Society
Idioma: Inglês

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Endometriosis

Bulun, Serdar E

Waltham, MA: Massachusetts Medical Society

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