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CEACAM6 acts as a receptor for adherent-invasive E. coli, supporting ileal mucosa colonization in Crohn disease

Barnich, Nicolas ; Carvalho, Frédéric A ; Glasser, Anne-Lise ; Darcha, Claude ; Jantscheff, Peter ; Allez, Matthieu ; Peeters, Harald ; Bommelaer, Gilles ; Desreumaux, Pierre ; Colombel, Jean-Frédéric ; Darfeuille-Michaud, Arlette

The Journal of clinical investigation, 2007-06, Vol.117 (6), p.1566-1574 [Periódico revisado por pares]

United States: American Society for Clinical Investigation

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Título:
CEACAM6 acts as a receptor for adherent-invasive E. coli, supporting ileal mucosa colonization in Crohn disease
Autor: Barnich, Nicolas ; Carvalho, Frédéric A ; Glasser, Anne-Lise ; Darcha, Claude ; Jantscheff, Peter ; Allez, Matthieu ; Peeters, Harald ; Bommelaer, Gilles ; Desreumaux, Pierre ; Colombel, Jean-Frédéric ; Darfeuille-Michaud, Arlette
Assuntos: Adolescent ; Adult ; Antigens, CD - genetics ; Antigens, CD - metabolism ; Bacterial Adhesion ; Base Sequence ; Case-Control Studies ; Causes of ; Cell adhesion ; Cell Adhesion Molecules - genetics ; Cell Adhesion Molecules - metabolism ; Cell Line ; Crohn Disease - immunology ; Crohn Disease - microbiology ; Crohn's disease ; Diseases ; Epithelial cells ; Escherichia coli ; Escherichia coli - pathogenicity ; Female ; GPI-Linked Proteins ; Humans ; Ileum - immunology ; Ileum - microbiology ; Inflammatory bowel diseases ; Intestinal Mucosa - immunology ; Intestinal Mucosa - microbiology ; Life Sciences ; Male ; Microvilli - immunology ; Microvilli - microbiology ; Middle Aged ; Recombinant Proteins - genetics ; Recombinant Proteins - metabolism ; RNA, Small Interfering - genetics ; Transfection
É parte de: The Journal of clinical investigation, 2007-06, Vol.117 (6), p.1566-1574
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
PMCID: PMC1868786
Descrição: The ileal mucosa of Crohn disease (CD) patients is abnormally colonized by adherent-invasive E. coli (AIEC) that are able to adhere to and invade intestinal epithelial cells. Here, we show that CD-associated AIEC strains adhere to the brush border of primary ileal enterocytes isolated from CD patients but not controls without inflammatory bowel disease. AIEC adhesion is dependent on type 1 pili expression on the bacterial surface and on carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) expression on the apical surface of ileal epithelial cells. We report also that CEACAM6 acts as a receptor for AIEC adhesion and is abnormally expressed by ileal epithelial cells in CD patients. In addition, our in vitro studies show that there is increased CEACAM6 expression in cultured intestinal epithelial cells after IFN-gamma or TNF-alpha stimulation and after infection with AIEC bacteria, indicating that AIEC can promote its own colonization in CD patients.
Editor: United States: American Society for Clinical Investigation
Idioma: Inglês

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CEACAM6 acts as a receptor for adherent-invasive E. coli, supporting ileal mucosa colonization in Crohn disease

Barnich, Nicolas ; Carvalho, Frédéric A ; Glasser, Anne-Lise ; Darcha, Claude ; Jantscheff, Peter ; Allez, Matthieu ; Peeters, Harald ; Bommelaer, Gilles ; Desreumaux, Pierre ; Colombel, Jean-Frédéric ; Darfeuille-Michaud, Arlette

United States: American Society for Clinical Investigation

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