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Multicenter Study of Method-Dependent Epidemiological Cutoff Values for Detection of Resistance in Candida spp. and Aspergillus spp. to Amphotericin B and Echinocandins for the Etest Agar Diffusion Method

Espinel-Ingroff, A ; Arendrup, M ; Cantón, E ; Cordoba, S ; Dannaoui, E ; García-Rodríguez, J ; Gonzalez, G M ; Govender, N P ; Martin-Mazuelos, E ; Lackner, M ; Lass-Flörl, C ; Linares Sicilia, M J ; Rodriguez-Iglesias, M A ; Pelaez, T ; Shields, R K ; Garcia-Effron, G ; Guinea, J ; Sanguinetti, M ; Turnidge, J

Antimicrobial agents and chemotherapy, 2017-01, Vol.61 (1) [Periódico revisado por pares]

United States: American Society for Microbiology

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Multicenter Study of Method-Dependent Epidemiological Cutoff Values for Detection of Resistance in Candida spp. and Aspergillus spp. to Amphotericin B and Echinocandins for the Etest Agar Diffusion Method
Autor: Espinel-Ingroff, A ; Arendrup, M ; Cantón, E ; Cordoba, S ; Dannaoui, E ; García-Rodríguez, J ; Gonzalez, G M ; Govender, N P ; Martin-Mazuelos, E ; Lackner, M ; Lass-Flörl, C ; Linares Sicilia, M J ; Rodriguez-Iglesias, M A ; Pelaez, T ; Shields, R K ; Garcia-Effron, G ; Guinea, J ; Sanguinetti, M ; Turnidge, J
Assuntos: Amphotericin B ; Amphotericin B - pharmacology ; Antifungal Agents ; Antifungal Agents - pharmacology ; Aspergillus ; Aspergillus - drug effects ; Aspergillus - growth & development ; Aspergillus - isolation & purification ; Aspergillus flavus ; Aspergillus fumigatus ; Candida ; Candida - drug effects ; Candida - growth & development ; Candida - isolation & purification ; Candida albicans ; Disk Diffusion Antimicrobial Tests ; Drug Resistance, Fungal ; Echinocandins ; Echinocandins - pharmacology ; Europe ; Latin America ; Life Sciences ; South Africa ; Susceptibility ; United States
É parte de: Antimicrobial agents and chemotherapy, 2017-01, Vol.61 (1)
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Citation Espinel-Ingroff A, Arendrup M, Cantón E, Cordoba S, Dannaoui E, García-Rodríguez J, Gonzalez GM, Govender NP, Martin-Mazuelos E, Lackner M, Lass-Flörl C, Linares Sicilia MJ, Rodriguez-Iglesias MA, Pelaez T, Shields RK, Garcia-Effron G, Guinea J, Sanguinetti M, Turnidge J. 2017. Multicenter study of method-dependent epidemiological cutoff values for detection of resistance in Candida spp. and Aspergillus spp. to amphotericin B and echinocandins for the Etest agar diffusion method. Antimicrob Agents Chemother 61:e01792-16. https://doi.org/10.1128/AAC.01792-16.
Descrição: Method-dependent Etest epidemiological cutoff values (ECVs) are not available for susceptibility testing of either Candida or Aspergillus species with amphotericin B or echinocandins. In addition, reference caspofungin MICs for Candida spp. are unreliable. Candida and Aspergillus species wild-type (WT) Etest MIC distributions (microorganisms in a species-drug combination with no detectable phenotypic resistance) were established for 4,341 Candida albicans, 113 C. dubliniensis, 1,683 C. glabrata species complex (SC), 709 C. krusei, 767 C. parapsilosis SC, 796 C. tropicalis, 1,637 Aspergillus fumigatus SC, 238 A. flavus SC, 321 A. niger SC, and 247 A. terreus SC isolates. Etest MICs from 15 laboratories (in Argentina, Europe, Mexico, South Africa, and the United States) were pooled to establish Etest ECVs. Anidulafungin, caspofungin, micafungin, and amphotericin B ECVs (in micrograms per milliliter) encompassing ≥97.5% of the statistically modeled population were 0.016, 0.5, 0.03, and 1 for C. albicans; 0.03, 1, 0.03, and 2 for C. glabrata SC; 0.06, 1, 0.25, and 4 for C. krusei; 8, 4, 2, and 2 for C. parapsilosis SC; and 0.03, 1, 0.12, and 2 for C. tropicalis The amphotericin B ECV was 0.25 μg/ml for C. dubliniensis and 2, 8, 2, and 16 μg/ml for the complexes of A. fumigatus, A. flavus, A. niger, and A. terreus, respectively. While anidulafungin Etest ECVs classified 92% of the Candida fks mutants evaluated as non-WT, the performance was lower for caspofungin (75%) and micafungin (84%) cutoffs. Finally, although anidulafungin (as an echinocandin surrogate susceptibility marker) and amphotericin B ECVs should identify Candida and Aspergillus isolates with reduced susceptibility to these agents using the Etest, these ECVs will not categorize a fungal isolate as susceptible or resistant, as breakpoints do.
Editor: United States: American Society for Microbiology
Idioma: Inglês

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Multicenter Study of Method-Dependent Epidemiological Cutoff Values for Detection of Resistance in Candida spp. and Aspergillus spp. to Amphotericin B and Echinocandins for the Etest Agar Diffusion Method

United States: American Society for Microbiology

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