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Influence of HEK293 metabolism on the production of viral vectors and vaccine

Petiot, Emma ; Cuperlovic-Culf, Miroslava ; Shen, Chun Fang ; Kamen, Amine

Vaccine, 2015-11, Vol.33 (44), p.5974-5981 [Periódico revisado por pares]

Netherlands: Elsevier Ltd

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Título:
Influence of HEK293 metabolism on the production of viral vectors and vaccine
Autor: Petiot, Emma ; Cuperlovic-Culf, Miroslava ; Shen, Chun Fang ; Kamen, Amine
Assuntos: Adenoviruses ; Allergy and Immunology ; Biosynthesis ; Carbon ; Cell culture ; Cell Culture Techniques ; Cell Line ; Drug Carriers - isolation & purification ; Drug Carriers - metabolism ; Epithelial Cells - metabolism ; Glucose ; HEK293 cell metabolism ; Humans ; Infections ; Influenza ; Lipids ; Metabolism ; Metabolites ; Metabolomics ; Physiology ; Polyamines ; Proteins ; Technology, Pharmaceutical ; Vaccines ; Vaccines - isolation & purification ; Vaccines - metabolism ; Vectors (Biology) ; Viral infections ; Viral production processes ; Viral vector and vaccine ; Viruses
É parte de: Vaccine, 2015-11, Vol.33 (44), p.5974-5981
Notas: ObjectType-Article-2
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Descrição: Highlights • There are critical changes in cell metabolism upon viral infection. • Production of live viruses for vaccine applications in HEK293 is often a biphasic process. • Understanding the metabolic shifts between cell growth and production phases is important for process intensification. • Results of published metabolic studies on HEK293 cells focusing on viral production are summarized. • Remaining challenges and the potential of HEK293 system for high yield production of viruses are underlined.
Editor: Netherlands: Elsevier Ltd
Idioma: Inglês

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Influence of HEK293 metabolism on the production of viral vectors and vaccine

Petiot, Emma ; Cuperlovic-Culf, Miroslava ; Shen, Chun Fang ; Kamen, Amine

Netherlands: Elsevier Ltd

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