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Seipin Deficiency Leads to Energy Dyshomeostasis via Inducing Hypothalamic Neuroinflammation and Aberrant Expression of Neuropeptides

Cui, Wenli ; Chen, Hong ; Lei, Lingfeng ; Wang, Wenru ; Lim, Kah-Leong ; Zhang, Chengwu ; Lu, Li

Neuromolecular medicine, 2024-05, Vol.26 (1), p.18-18 [Periódico revisado por pares]

New York: Springer US

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Título:
Seipin Deficiency Leads to Energy Dyshomeostasis via Inducing Hypothalamic Neuroinflammation and Aberrant Expression of Neuropeptides
Autor: Cui, Wenli ; Chen, Hong ; Lei, Lingfeng ; Wang, Wenru ; Lim, Kah-Leong ; Zhang, Chengwu ; Lu, Li
Assuntos: Agouti-Related Protein - genetics ; Animals ; Antidiabetics ; Appetite ; Biomedical and Life Sciences ; Biomedicine ; Brain ; Brief Report ; Diabetes mellitus ; Energy ; Energy balance ; Energy metabolism ; Energy Metabolism - drug effects ; Food ; Gene Expression Regulation - drug effects ; Glucose ; GTP-Binding Protein gamma Subunits - genetics ; Homeostasis ; Hyperlipidemia ; Hypoglycemic Agents - pharmacology ; Hypoglycemic Agents - therapeutic use ; Hypothalamus ; Hypothalamus - metabolism ; Inflammation ; Internal Medicine ; Lipid metabolism ; Lipodystrophy ; Male ; Medicine ; Metabolic disorders ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Neuroinflammatory Diseases - etiology ; Neurology ; Neuropeptides ; Neuropeptides - deficiency ; Neuropeptides - genetics ; Neurosciences ; Nutrition research ; Peptides ; Pro-Opiomelanocortin - biosynthesis ; Pro-Opiomelanocortin - genetics ; Proopiomelanocortin ; Proteins ; Rosiglitazone ; Rosiglitazone - pharmacology
É parte de: Neuromolecular medicine, 2024-05, Vol.26 (1), p.18-18
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: Seipin is a key regulator of lipid metabolism, the deficiency of which leads to severe lipodystrophy. Hypothalamus is the pivotal center of brain that modulates appetite and energy homeostasis, where Seipin is abundantly expressed. Whether and how Seipin deficiency leads to systemic metabolic disorders via hypothalamus-involved energy metabolism dysregulation remains to be elucidated. In the present study, we demonstrated that Seipin-deficiency induced hypothalamic inflammation, reduction of anorexigenic pro-opiomelanocortin (POMC), and elevation of orexigenic agonist-related peptide (AgRP). Importantly, administration of rosiglitazone, a thiazolidinedione antidiabetic agent, rescued POMC and AgRP expression, suppressed hypothalamic inflammation, and restored energy homeostasis in Seipin knockout mice. Our findings offer crucial insights into the mechanism of Seipin deficiency-associated energy imbalance and indicates that rosiglitazone could serve as potential intervening agent towards metabolic disorders linked to Seipin.
Editor: New York: Springer US
Idioma: Inglês

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Seipin Deficiency Leads to Energy Dyshomeostasis via Inducing Hypothalamic Neuroinflammation and Aberrant Expression of Neuropeptides

Cui, Wenli ; Chen, Hong ; Lei, Lingfeng ; Wang, Wenru ; Lim, Kah-Leong ; Zhang, Chengwu ; Lu, Li

New York: Springer US

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