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Kinetic Resolution of Secondary Alcohols Catalyzed by Chiral Phosphoric Acids

Harada, Shingo ; Kuwano, Satoru ; Yamaoka, Yousuke ; Yamada, Ken-ichi ; Takasu, Kiyosei

Angewandte Chemie (International ed.), 2013-09, Vol.52 (39), p.10227-10230 [Periódico revisado por pares]

Weinheim: WILEY-VCH Verlag

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Título:
Kinetic Resolution of Secondary Alcohols Catalyzed by Chiral Phosphoric Acids
Autor: Harada, Shingo ; Kuwano, Satoru ; Yamaoka, Yousuke ; Yamada, Ken-ichi ; Takasu, Kiyosei
Assuntos: Acylation ; Alcohols ; Alcohols - chemistry ; Ambient temperature ; asymmetric acylation ; Carboxylic acids ; Catalysis ; chiral alcohols ; Functional groups ; kinetic resolution ; Kinetics ; organocatalysis ; Phosphoric acid ; Phosphoric Acids - chemistry ; Reaction kinetics ; Selectivity ; Stereoisomerism
É parte de: Angewandte Chemie (International ed.), 2013-09, Vol.52 (39), p.10227-10230
Notas: MEXT
We thank MEXT (Japan) for financial support (Grants-in-Aid for Scientific Research and Platform for Drug Design, Discovery, and Development).
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ArticleID:ANIE201304281
ark:/67375/WNG-3SVVM3PG-Z
We thank MEXT (Japan) for financial support (Grants‐in‐Aid for Scientific Research and Platform for Drug Design, Discovery, and Development).
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Descrição: Acid instead of base: Kinetic resolution of secondary alcohols is realized using chiral Brønsted acid catalyzed acylation instead of the conventional basic conditions. A broad range of functional groups are tolerated, such as aldehydes, carboxylic acids, and enoates. The selectivity factor (s) reaches up to 215 at ambient temperature.
Editor: Weinheim: WILEY-VCH Verlag
Idioma: Inglês

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Kinetic Resolution of Secondary Alcohols Catalyzed by Chiral Phosphoric Acids

Harada, Shingo ; Kuwano, Satoru ; Yamaoka, Yousuke ; Yamada, Ken-ichi ; Takasu, Kiyosei

Weinheim: WILEY-VCH Verlag

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