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Role of the CCL2‐CCR2 signalling axis in cancer: Mechanisms and therapeutic targeting

Xu, Maosen ; Wang, Yang ; Xia, Ruolan ; Wei, Yuquan ; Wei, Xiawei

Cell proliferation, 2021-10, Vol.54 (10), p.e13115-n/a [Periódico revisado por pares]

Chichester: John Wiley & Sons, Inc

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Título:
Role of the CCL2‐CCR2 signalling axis in cancer: Mechanisms and therapeutic targeting
Autor: Xu, Maosen ; Wang, Yang ; Xia, Ruolan ; Wei, Yuquan ; Wei, Xiawei
Assuntos: Angiogenesis ; Biomarkers ; Bone cancer ; Breast cancer ; Cancer ; CC chemokine receptors ; CCR2 protein ; Cell adhesion & migration ; Cell migration ; Cervical cancer ; Chemokines ; Clinical trials ; Colorectal cancer ; Kidney cancer ; Kinases ; Ligands ; Liver cancer ; Medical prognosis ; Metastasis ; Microenvironments ; Monocyte chemoattractant protein 1 ; Ovarian cancer ; Pancreatic cancer ; Pathogenesis ; Prostate cancer ; Proteins ; Review ; Reviews ; Signal transduction ; Signaling ; Therapeutic targets ; Thyroid cancer ; Tumorigenesis ; Tumors
É parte de: Cell proliferation, 2021-10, Vol.54 (10), p.e13115-n/a
Notas: Maosen Xu and Yang Wang contributed equally to the work.
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Descrição: The chemokine ligand CCL2 and its receptor CCR2 are implicated in the initiation and progression of various cancers. CCL2 can activate tumour cell growth and proliferation through a variety of mechanisms. By interacting with CCR2, CCL2 promotes cancer cell migration and recruits immunosuppressive cells to the tumour microenvironment, favouring cancer development. Over the last several decades, a series of studies have been conducted to explore the CCL2‐CCR2 signalling axis function in malignancies. Therapeutic strategies targeting the CCL2‐ CCR2 axis have also shown promising effects, enriching our approaches for fighting against cancer. In this review, we summarize the role of the CCL2‐CCR2 signalling axis in tumorigenesis and highlight recent studies on CCL2‐CCR2 targeted therapy, focusing on preclinical studies and clinical trials. The chemokine ligand CCL2 and its receptor CCR2 are implicated in the initiation and progression of various cancers. The CCL2‐CCR2 signalling axis plays a critical role in the promotion of pathological angiogenesis, the survival and invasion of tumour cells, and the recruitment of immune inhibitory cells. Therefore, CCL2 and CCR2 enable us to explore the sophisticated mechanisms underlying cancer development and provide potential options for treating malignant tumours.
Editor: Chichester: John Wiley & Sons, Inc
Idioma: Inglês

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Role of the CCL2‐CCR2 signalling axis in cancer: Mechanisms and therapeutic targeting

Xu, Maosen ; Wang, Yang ; Xia, Ruolan ; Wei, Yuquan ; Wei, Xiawei

Chichester: John Wiley & Sons, Inc

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