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Additional file 11 of CRISPR/dCAS9-mediated DNA demethylation screen identifies functional epigenetic determinants of colorectal cancer

Tejedor, Juan Ramón ; Peñarroya, Alfonso ; Gancedo-Verdejo, Javier ; Santamarina-Ojeda, Pablo ; Pérez, Raúl F. ; López-Tamargo, Sara ; Díez-Borge, Ana ; Alba-Linares, Juan J. ; González-del-Rey, Nerea ; Urdinguio, Rocío G. ; Mangas, Cristina ; Roberti, Annalisa ; López, Virginia ; Morales-Ruiz, Teresa ; Ariza, Rafael R. ; Roldán-Arjona, Teresa ; Meijón, Mónica ; Valledor, Luis ; Cañal, María Jesús ; Fernández-Martínez, Daniel ; Fernández-Hevia, María ; Jiménez-Fonseca, Paula ; García-Flórez, Luis J. ; Fernández, Agustín F. ; Fraga, Mario F.

figshare 2023

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  • Título:
    Additional file 11 of CRISPR/dCAS9-mediated DNA demethylation screen identifies functional epigenetic determinants of colorectal cancer
  • Autor: Tejedor, Juan Ramón ; Peñarroya, Alfonso ; Gancedo-Verdejo, Javier ; Santamarina-Ojeda, Pablo ; Pérez, Raúl F. ; López-Tamargo, Sara ; Díez-Borge, Ana ; Alba-Linares, Juan J. ; González-del-Rey, Nerea ; Urdinguio, Rocío G. ; Mangas, Cristina ; Roberti, Annalisa ; López, Virginia ; Morales-Ruiz, Teresa ; Ariza, Rafael R. ; Roldán-Arjona, Teresa ; Meijón, Mónica ; Valledor, Luis ; Cañal, María Jesús ; Fernández-Martínez, Daniel ; Fernández-Hevia, María ; Jiménez-Fonseca, Paula ; García-Flórez, Luis J. ; Fernández, Agustín F. ; Fraga, Mario F.
  • Assuntos: FOS: Biological sciences ; Genetics
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  • Descrição: Additional file 11: Fig. S2. Results of the CRISPR-dCas9 demethylation screen strategy in HCT116 cells. A Boxplots illustrating the Scaled Robust Z-score data observed for the indicated gene promoters in the context of HCT116 cells transduced with dCas9-TET1 (top), dCas9-TET1-IM (middle) or dCas9-VP64 (bottom) constructs. Genes highlighted in orange reflect those epigenetic modulations that resulted in statistically significant changes in the proliferation rate of HCT116 cells, and control conditions are highlighted in red. B Venn diagrams depicting the overlap of significant hits obtained in the different screen strategies performed in HCT116 cells.
  • Editor: figshare
  • Data de criação/publicação: 2023
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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