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Flavonoids as Anticancer Agents

Kopustinskiene, Dalia M ; Jakstas, Valdas ; Savickas, Arunas ; Bernatoniene, Jurga

Nutrients, 2020-02, Vol.12 (2), p.457 [Periódico revisado por pares]

Switzerland: MDPI AG

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Título:
Flavonoids as Anticancer Agents
Autor: Kopustinskiene, Dalia M ; Jakstas, Valdas ; Savickas, Arunas ; Bernatoniene, Jurga
Assuntos: Antineoplastic Agents ; Antioxidants ; Antitumor activity ; Apoptosis ; Apoptosis - drug effects ; Autophagy ; Autophagy - drug effects ; Beverages ; Bioavailability ; Biological Availability ; Breast cancer ; cancer ; Cell cycle ; Cell Cycle - drug effects ; Cell proliferation ; Cocoa ; Diet ; Dose-Response Relationship, Drug ; Enzymatic activity ; Flavanols ; Flavones ; Flavonoids ; Flavonoids - chemistry ; Flavonoids - isolation & purification ; Flavonoids - metabolism ; Flavonoids - pharmacology ; Flavonols ; Free Radical Scavengers - metabolism ; Fruit - chemistry ; Fruits ; Green tea ; Homeostasis ; Humans ; Inflammation ; Invasiveness ; Isoflavonoids ; Metabolites ; mitochondria ; Molecular Conformation ; Neoplasms - metabolism ; Neoplasms - pathology ; Oxidants ; Oxidizing agents ; Phagocytosis ; Plants ; Plants (botany) ; Polyphenols ; pro-oxidants ; Reactive Oxygen Species - metabolism ; Review ; ros ; Scavenging ; Tea ; Vegetables - chemistry ; Wine
É parte de: Nutrients, 2020-02, Vol.12 (2), p.457
Descrição: Flavonoids are polyphenolic compounds subdivided into 6 groups: isoflavonoids, flavanones, flavanols, flavonols, flavones and anthocyanidins found in a variety of plants. Fruits, vegetables, plant-derived beverages such as green tea, wine and cocoa-based products are the main dietary sources of flavonoids. Flavonoids have been shown to possess a wide variety of anticancer effects: they modulate reactive oxygen species (ROS)-scavenging enzyme activities, participate in arresting the cell cycle, induce apoptosis, autophagy, and suppress cancer cell proliferation and invasiveness. Flavonoids have dual action regarding ROS homeostasis-they act as antioxidants under normal conditions and are potent pro-oxidants in cancer cells triggering the apoptotic pathways and downregulating pro-inflammatory signaling pathways. This article reviews the biochemical properties and bioavailability of flavonoids, their anticancer activity and its mechanisms of action.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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Flavonoids as Anticancer Agents

Kopustinskiene, Dalia M ; Jakstas, Valdas ; Savickas, Arunas ; Bernatoniene, Jurga

Switzerland: MDPI AG

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