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LOWER LEVELS OF VITAMIN D CORRELATE WITH CLINICAL DISEASE ACTIVITY AND QUALITY OF LIFE IN INFLAMMATORY BOWEL DISEASE

Castro, Francisca Dias De ; Magalhães, Joana ; Carvalho, Pedro Boal ; Moreira, Maria João ; Mota, Paula ; Cotter, José

Arquivos de gastroenterologia, 2015-12, Vol.52 (4), p.260-265 [Periódico revisado por pares]

Brazil: Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia e Outras Especialidades - IBEPEGE

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Título:
LOWER LEVELS OF VITAMIN D CORRELATE WITH CLINICAL DISEASE ACTIVITY AND QUALITY OF LIFE IN INFLAMMATORY BOWEL DISEASE
Autor: Castro, Francisca Dias De ; Magalhães, Joana ; Carvalho, Pedro Boal ; Moreira, Maria João ; Mota, Paula ; Cotter, José
Assuntos: Adult ; Colitis, Ulcerative - blood ; Colitis, Ulcerative - complications ; Colitis, Ulcerative - psychology ; Crohn Disease - blood ; Crohn Disease - complications ; Crohn Disease - psychology ; Cross-Sectional Studies ; Doenças inflamatórias intestinais ; Female ; GASTROENTEROLOGY & HEPATOLOGY ; Humans ; Male ; Qualidade de vida ; Quality of Life - psychology ; Severity of Illness Index ; Vitamin D - analogs & derivatives ; Vitamin D - blood ; Vitamin D Deficiency - blood ; Vitamin D Deficiency - etiology ; Vitamina D
É parte de: Arquivos de gastroenterologia, 2015-12, Vol.52 (4), p.260-265
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Inflammatory bowel disease, comprising Crohn's disease and ulcerative colitis, is a group of debilitating conditions associated with deregulated mucosal immune response. Vitamin D has been implicated in immune response and gastrointestinal function. To investigate the correlation between serum vitamin D levels and disease activity and quality of life in patients with inflammatory bowel disease. This cross-sectional study enrolled ambulatory patients with inflammatory bowel disease and assessed clinical disease activity and quality of life (Short Inflammatory Bowel Disease Questionnaire [SIBDQ]). Vitamin D levels were determined via serum 25-hydroxyvitamin D measurement; deficiency was defined as values <20 ng/mL. Statistical analysis was performed with SPSS vs 20.0. A total of 76 patients were enrolled, 19 with ulcerative colitis (25%) and 57 with Crohn's disease (75%). Overall, mean serum 25-hydroxyvitamin D levels were low (26.0±10.0 ng/mL), while those in patients with Crohn's disease were significantly lower than ulcerative colitis (24.6±8.0 vs 30.0±12.5 ng/mL; P=0.032). Vitamin D deficiency was found in 30% of patients. Patients who were in clinical remission were found to have higher levels of vitamin D than those who were not in remission (28.0±10.3 vs 21.6±6.0 ng/mL, P=0.001). Inflammatory bowel disease patients with SIBDQ scores <50 were found to have significantly lower mean vitamin D levels compared with patients who had SIBDQ scores ≥50 (23.4±6.9 vs 27.9±10.8 ng/mL, P=0.041). A high proportion of patients with inflammatory bowel disease were vitamin D deficient, particularly patients with Crohn's disease. Both clinical disease activity and quality of life correlated significantly with lower levels of vitamin D, illustrating a clear need for supplementation in patients with inflammatory bowel disease.
Editor: Brazil: Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia e Outras Especialidades - IBEPEGE
Idioma: Inglês;Português

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LOWER LEVELS OF VITAMIN D CORRELATE WITH CLINICAL DISEASE ACTIVITY AND QUALITY OF LIFE IN INFLAMMATORY BOWEL DISEASE

Castro, Francisca Dias De ; Magalhães, Joana ; Carvalho, Pedro Boal ; Moreira, Maria João ; Mota, Paula ; Cotter, José

Brazil: Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia e Outras Especialidades - IBEPEGE

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