Idioma:

The Anatomy and Physiology of the Sinoatrial Node-A Contemporary Review

MONFREDI, OLIVER ; DOBRZYNSKI, HALINA ; MONDAL, TAPAS ; BOYETT, MARK R. ; MORRIS, GWILYM M.

Pacing and clinical electrophysiology, 2010-11, Vol.33 (11), p.1392-1406 [Periódico revisado por pares]

Malden, USA: Blackwell Publishing Inc

Texto completo disponível

Citações Citado por

Enviar para

Título:
The Anatomy and Physiology of the Sinoatrial Node-A Contemporary Review
Autor: MONFREDI, OLIVER ; DOBRZYNSKI, HALINA ; MONDAL, TAPAS ; BOYETT, MARK R. ; MORRIS, GWILYM M.
Assuntos: Aging ; Animals ; Arrhythmias, Cardiac - physiopathology ; Atrial Function, Right - physiology ; Biological and medical sciences ; Biological Clocks - physiology ; Diabetes Mellitus, Type 2 - physiopathology ; Dogs ; electrophysiology ; Female ; Fundamental and applied biological sciences. Psychology ; Gap Junctions - physiology ; Heart ; Heart Failure - physiopathology ; Humans ; ion channels ; Ion Channels - physiology ; Mice ; pacemaking ; Physical Endurance - physiology ; Rats ; Sick Sinus Syndrome - genetics ; Sick Sinus Syndrome - physiopathology ; sinoatrial node ; Sinoatrial Node - anatomy & histology ; Sinoatrial Node - physiology ; Vertebrates: cardiovascular system
É parte de: Pacing and clinical electrophysiology, 2010-11, Vol.33 (11), p.1392-1406
Notas: istex:C86014775ADF75C57A5CAF4895F53A688AAA463F
ArticleID:PACE2838
ark:/67375/WNG-NLSQG9L8-N
Work was supported by grants from the British Heart Foundation, Medtronic Inc., British Cardiovascular Society, Bristol‐Myers‐Squibb, and BBSRC.
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: The sinoatrial node is the primary pacemaker of the heart. Nodal dysfunction with aging, heart failure, atrial fibrillation, and even endurance athletic training can lead to a wide variety of pathological clinical syndromes. Recent work utilizing molecular markers to map the extent of the node, along with the delineation of a novel paranodal area intermediate in characteristics between the node and the surrounding atrial muscle, has shown that pacemaker tissue is more widely spread in the right atrium than previously appreciated. This can explain the phenomenon of a “wandering pacemaker” and concomitant changes in the P‐wave morphology. Extensive knowledge now exists regarding the molecular architecture of the node (in particular, the expression of ion channels) and how this relates to pacemaking. This review is an up‐to‐date summary of the current state of our appreciation of the above topics. (PACE 2010; 1392–1406)
Editor: Malden, USA: Blackwell Publishing Inc
Idioma: Inglês

Links

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

The Anatomy and Physiology of the Sinoatrial Node-A Contemporary Review

MONFREDI, OLIVER ; DOBRZYNSKI, HALINA ; MONDAL, TAPAS ; BOYETT, MARK R. ; MORRIS, GWILYM M.

Malden, USA: Blackwell Publishing Inc

Buscando em bases de dados remotas. Favor aguardar.