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Parametric fMRI of paced motor responses uncovers novel whole-brain imaging biomarkers in spinocerebellar ataxia type 3

Duarte, João Valente ; Faustino, Ricardo ; Lobo, Mercês ; Cunha, Gil ; Nunes, César ; Ferreira, Carlos ; Januário, Cristina ; Castelo-Branco, Miguel

Human brain mapping, 2016-10, Vol.37 (10), p.3656-3668 [Periódico revisado por pares]

United States: Blackwell Publishing Ltd

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Título:
Parametric fMRI of paced motor responses uncovers novel whole-brain imaging biomarkers in spinocerebellar ataxia type 3
Autor: Duarte, João Valente ; Faustino, Ricardo ; Lobo, Mercês ; Cunha, Gil ; Nunes, César ; Ferreira, Carlos ; Januário, Cristina ; Castelo-Branco, Miguel
Assuntos: Adult ; Age Factors ; Brain Mapping - methods ; cerebellar degeneration ; Cerebrovascular Circulation - physiology ; Female ; Fingers - physiology ; Humans ; Image Processing, Computer-Assisted - methods ; imaging biomarker ; Machado-Joseph Disease - diagnostic imaging ; Machado-Joseph Disease - genetics ; Machado-Joseph Disease - physiopathology ; Magnetic Resonance Imaging - methods ; Male ; Middle Aged ; Motor Activity - physiology ; movement disorder ; Organ Size ; Oxygen - blood ; parametric functional MRI ; Sensitivity and Specificity ; spinocerebellar ataxia type 3 ; voxel-based morphometry ; Young Adult
É parte de: Human brain mapping, 2016-10, Vol.37 (10), p.3656-3668
Notas: istex:94E5FD7D2550960E34F263A410DEA0F2A308510E
ark:/67375/WNG-FBC6ZPR7-S
UID/NEU/04539/2013-COMPETE - No. POCI-01-0145-FEDER-007440; No. CENTRO-07-ST24-FEDER-00205
Portuguese Foundation for Science and Technology - No. FCT - SFRH/BD/69735/2010
ArticleID:HBM23266
J.V. Duarte and R. Faustino contributed equally to this work.
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Machado‐Joseph Disease, inherited type 3 spinocerebellar ataxia (SCA3), is the most common form worldwide. Neuroimaging and neuropathology have consistently demonstrated cerebellar alterations. Here we aimed to discover whole‐brain functional biomarkers, based on parametric performance‐level‐dependent signals. We assessed 13 patients with early SCA3 and 14 healthy participants. We used a combined parametric behavioral/functional neuroimaging design to investigate disease fingerprints, as a function of performance levels, coupled with structural MRI and voxel‐based morphometry. Functional magnetic resonance imaging (fMRI) was designed to parametrically analyze behavior and neural responses to audio‐paced bilateral thumb movements at temporal frequencies of 1, 3, and 5 Hz. Our performance‐level‐based design probing neuronal correlates of motor coordination enabled the discovery that neural activation and behavior show critical loss of parametric modulation specifically in SCA3, associated with frequency‐dependent cortico/subcortical activation/deactivation patterns. Cerebellar/cortical rate‐dependent dissociation patterns could clearly differentiate between groups irrespective of grey matter loss. Our findings suggest functional reorganization of the motor network and indicate a possible role of fMRI as a tool to monitor disease progression in SCA3. Accordingly, fMRI patterns proved to be potential biomarkers in early SCA3, as tested by receiver operating characteristic analysis of both behavior and neural activation at different frequencies. Discrimination analysis based on BOLD signal in response to the applied parametric finger‐tapping task significantly often reached >80% sensitivity and specificity in single regions‐of‐interest.Functional fingerprints based on cerebellar and cortical BOLD performance dependent signal modulation can thus be combined as diagnostic and/or therapeutic targets in hereditary ataxia. Hum Brain Mapp 37:3656–3668, 2016. © 2016 Wiley Periodicals, Inc.
Editor: United States: Blackwell Publishing Ltd
Idioma: Inglês

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Parametric fMRI of paced motor responses uncovers novel whole-brain imaging biomarkers in spinocerebellar ataxia type 3

Duarte, João Valente ; Faustino, Ricardo ; Lobo, Mercês ; Cunha, Gil ; Nunes, César ; Ferreira, Carlos ; Januário, Cristina ; Castelo-Branco, Miguel

United States: Blackwell Publishing Ltd

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