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Maternal plasma levels of vascular endothelial growth factor in normotensive pregnancies and in pregnancies complicated by pre-eclampsia

SHARKEY, A. M. ; COOPER, J. C. ; BALMFORTH, J. R. ; MCLAREN, J. ; CLARK, D. E. ; CHARNOCK-JONES, D. S. ; MORRIS, N. H. ; SMITH, S. K.

European journal of clinical investigation, 1996-12, Vol.26 (12), p.1182-1185 [Periódico revisado por pares]

Oxford BSL: Blackwell Science Ltd

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Título:
Maternal plasma levels of vascular endothelial growth factor in normotensive pregnancies and in pregnancies complicated by pre-eclampsia
Autor: SHARKEY, A. M. ; COOPER, J. C. ; BALMFORTH, J. R. ; MCLAREN, J. ; CLARK, D. E. ; CHARNOCK-JONES, D. S. ; MORRIS, N. H. ; SMITH, S. K.
Assuntos: Adolescent ; Adult ; Biological and medical sciences ; Birth Weight ; Blood Pressure ; Diseases of mother, fetus and pregnancy ; Endothelial Growth Factors - blood ; Endothelium ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Lymphokines - blood ; Medical sciences ; pre-eclampsia ; Pre-Eclampsia - blood ; Pre-Eclampsia - etiology ; pregnancy ; Pregnancy - blood ; Pregnancy Complications - blood ; Pregnancy. Fetus. Placenta ; Vascular Endothelial Growth Factor A ; Vascular Endothelial Growth Factors ; VEGF
É parte de: European journal of clinical investigation, 1996-12, Vol.26 (12), p.1182-1185
Notas: ArticleID:ECI83
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ark:/67375/WNG-TRRSDQHP-W
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: We have measured the level of vascular endothelial growth factor (VEGF) in maternal plasma during normotensive pregnancy and in pregnancies complicated by pre‐eclampsia. VEGF was measured using a competitive enzyme immunoassay. Plasma VEGF was significantly elevated (P<0.0001) in the pre‐eclamptic group (median value 32.7 ng mL−1, range 10.3–64.0), compared with the normotensive group (median value 11.7 ng mL−1, range 6.3–24.3). VEGF is a potent regulator of endothelial cell function. The increased level found in women with pre‐eclampsia indicates that VEGF may be involved in the maternal endothelial cell dysfunction associated with this condition. An increase in VEGF, a potent regulator of microvascular permeability, may also contribute to the extravasation of plasma proteins and the subsequent development of proteinuria, both characteristic features of pre‐eclampsia.
Editor: Oxford BSL: Blackwell Science Ltd
Idioma: Inglês

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Maternal plasma levels of vascular endothelial growth factor in normotensive pregnancies and in pregnancies complicated by pre-eclampsia

SHARKEY, A. M. ; COOPER, J. C. ; BALMFORTH, J. R. ; MCLAREN, J. ; CLARK, D. E. ; CHARNOCK-JONES, D. S. ; MORRIS, N. H. ; SMITH, S. K.

Oxford BSL: Blackwell Science Ltd

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