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Reduced renal reabsorption of 1,5-anhydro-D-glucitol in diabetic rats and mice

Kametani, S ; Hashimoto, Y ; Yamanouchi, T ; Akanuma, Y ; Akanuma, H

Journal of biochemistry (Tokyo), 1987-12, Vol.102 (6), p.1599-1607 [Periódico revisado por pares]

Oxford: Oxford University Press

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Título:
Reduced renal reabsorption of 1,5-anhydro-D-glucitol in diabetic rats and mice
Autor: Kametani, S ; Hashimoto, Y ; Yamanouchi, T ; Akanuma, Y ; Akanuma, H
Assuntos: 1,5-anhydro-D-glucitol ; Absorption ; Animals ; Biological and medical sciences ; Carbon Radioisotopes ; Chromatography, High Pressure Liquid ; Deoxy Sugars - metabolism ; Deoxyglucose - blood ; Deoxyglucose - metabolism ; Deoxyglucose - urine ; diabetes mellitus ; Diabetes Mellitus, Experimental - metabolism ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; experimental diabetes ; Gas Chromatography-Mass Spectrometry ; Glycosuria - urine ; kidney ; Kidney - metabolism ; kidneys ; Male ; Medical sciences ; Mice ; Mice, Inbred ICR ; Rats ; Rats, Inbred Strains ; reabsorption ; Tissue Distribution
É parte de: Journal of biochemistry (Tokyo), 1987-12, Vol.102 (6), p.1599-1607
Notas: istex:7201219BC5280249714C917057D884AC94F44879
1 To whom correspondence should be addressed.
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Descrição: A stable amount, approximately 60 μg, of 1,5-anhydro-D-glucitol (AG) was detected in the 24-h-urine of normal young rats fed ad libitum. Upon administration of streptozotocin (STZ), this amount was temporarily elevated to as much as 1.1 mg and AG was concomitantly removed from the circulation. The plasma AG level stayed almost null thereafter while the acutely elevated urinary AG excretion declined within 24 h to another stable excretion level that was three times as high as that of the untreated rats. In contrast, glucosuria developed much more slowly in the drug-treated rats. Normal rats and mice retained exogenous [14C]AG to a considerable extent and the radioactivity was distributed all over the body. Only a marginal fraction of the radioactivity was excreted as expired CO2. The radioactivities retained in the body and excreted into the urine were mostly attributed to unmetabolized AG. The observations of AG's metabolic stability and its relatively low level of leakage into urine suggested the concept of effective renal AG reabsorption. On the other hand, the rats with STZ-induced diabetes and NOD-mice with spontaneously developed diabetes retained little of the radioactive AG in their bodies; most of the injected radioactivity was recovered in the urine within 24 h. This observation was interpreted as due to reduced renal AG reabsorption in these animals. The concept of reduction in renal AG reabsorption in diabetes could account for the reduced plasma AG level generally observed in human diabetic cases.
Editor: Oxford: Oxford University Press
Idioma: Inglês

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Reduced renal reabsorption of 1,5-anhydro-D-glucitol in diabetic rats and mice

Kametani, S ; Hashimoto, Y ; Yamanouchi, T ; Akanuma, Y ; Akanuma, H

Oxford: Oxford University Press

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