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Maternal prenatal lead levels and neonatal brain volumes: Testing moderations by maternal depressive symptoms and family income

Wylie, Amanda C. ; Short, Sarah J. ; Fry, Rebecca C. ; Mills-Koonce, W. Roger ; Propper, Cathi B.

Neurotoxicology and teratology, 2024-03, Vol.102, p.107322-107322, Article 107322 [Periódico revisado por pares]

United States: Elsevier Inc

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  • Título:
    Maternal prenatal lead levels and neonatal brain volumes: Testing moderations by maternal depressive symptoms and family income
  • Autor: Wylie, Amanda C. ; Short, Sarah J. ; Fry, Rebecca C. ; Mills-Koonce, W. Roger ; Propper, Cathi B.
  • Assuntos: Brain ; Brain development ; Depression ; Depression - complications ; Female ; Fetal development ; Humans ; Infant ; Infant, Newborn ; Lead ; Lead - toxicity ; Mothers - psychology ; Neuroimaging ; Pregnancy ; Prenatal Exposure Delayed Effects ; Prenatal programming
  • É parte de: Neurotoxicology and teratology, 2024-03, Vol.102, p.107322-107322, Article 107322
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
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  • Descrição: There is considerable evidence that prenatal lead exposure is detrimental to child cognitive and socio-emotional development. Further evidence suggests that the effects of prenatal lead on developmental outcomes may be conditional upon exposure to social stressors, such as maternal depression and low socioeconomic status. However, no studies have examined associations between these co-occurring stressors during pregnancy and neonatal brain volumes. Leveraging a sample of 101 mother-infant dyads followed beginning in mid-pregnancy, we examined the main effects of prenatal urinary lead levels on neonatal lateralized brain volumes (left and right hippocampus, amygdala, cerebellum, frontal lobes) and total gray matter. We additionally tested for moderations between lead and depressive symptoms and between lead and family income relative to the federal poverty level (FPL) on the same neurodevelopmental outcomes. Analyses of main effects indicated that prenatal lead was significantly (ps < 0.05) associated with reduced right and left amygdala volumes (βs = −0.23- -0.20). The testing and probing of cross-product interaction terms using simple slopes indicated that the negative effect of lead on the left amygdala was conditional upon mothers having low depressive symptoms or high income relative to the FPL. We interpret the results in the context of trajectories of prenatal and postnatal brain development and susceptibility to low levels of prenatal lead in the context of other social stressors. •High maternal prenatal lead predicted smaller neonatal amygdala brain volumes.•Mid-pregnancy may reflect a sensitive period for the fetal amygdala to lead.•Effects to offspring left amygdala were unique to mothers with low social stress.•Neonates with low maternal social stress may be more susceptible to prenatal lead.
  • Editor: United States: Elsevier Inc
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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