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An evaluation of /sup 99m/Tc-TMP as a myocardial imaging agent

Jehangir, M. ; Subramanian, G. ; McAfee, J.G. ; Thomas, F.D. ; Gagne, G. ; Zapf-Longo, C. ; Ritter-Hrncirik, C.

J. Nucl. Med.; (United States), 1985, Vol.26:5

United States

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Título:
An evaluation of /sup 99m/Tc-TMP as a myocardial imaging agent
Autor: Jehangir, M. ; Subramanian, G. ; McAfee, J.G. ; Thomas, F.D. ; Gagne, G. ; Zapf-Longo, C. ; Ritter-Hrncirik, C.
Assuntos: 550601 - Medicine- Unsealed Radionuclides in Diagnostics ; 560161 - Radionuclide Effects, Kinetics, & Toxicology- Man ; 560162 - Radionuclide Effects, Kinetics, & Toxicology- Animals, Plants, Microorganisms, & Cells ; ANIMALS ; BETA DECAY RADIOISOTOPES ; BETA-MINUS DECAY RADIOISOTOPES ; BIOCHEMICAL REACTION KINETICS ; BODY ; CARDIOVASCULAR SYSTEM ; CATS ; CHEMICAL PREPARATION ; CLEARANCE ; COMPARATIVE EVALUATIONS ; COUNTING TECHNIQUES ; DAYS LIVING RADIOISOTOPES ; DIAGNOSTIC TECHNIQUES ; DIAGNOSTIC USES ; DISTRIBUTION ; DMSO ; DOGS ; DRUGS ; ELECTRON CAPTURE RADIOISOTOPES ; EVALUATION ; EXCRETION ; HEART ; HEAVY NUCLEI ; HOURS LIVING RADIOISOTOPES ; INJECTION ; INTAKE ; INTERMEDIATE MASS NUCLEI ; INTRAVENOUS INJECTION ; ISOMERIC TRANSITION ISOTOPES ; ISOTOPES ; KINETICS ; LABELLED COMPOUNDS ; LABELLING ; MACACUS ; MAMMALS ; MAN ; MONKEYS ; MUSCLES ; MYOCARDIUM ; NUCLEI ; ODD-EVEN NUCLEI ; ORGANIC COMPOUNDS ; ORGANIC SULFUR COMPOUNDS ; ORGANS ; PRIMATES ; RABBITS ; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT ; RADIOISOTOPE SCANNING ; RADIOISOTOPES ; RADIOLOGY AND NUCLEAR MEDICINE ; RADIONUCLIDE KINETICS ; RADIOPHARMACEUTICALS ; RATS ; REACTION KINETICS ; RENAL CLEARANCE ; RODENTS ; SCINTISCANNING ; SECONDS LIVING RADIOISOTOPES ; SULFOXIDES ; SYNTHESIS ; TECHNETIUM 99 ; TECHNETIUM ISOTOPES ; THALLIUM 201 ; THALLIUM ISOTOPES ; TISSUE DISTRIBUTION ; UPTAKE ; USES ; VERTEBRATES ; YEARS LIVING RADIOISOTOPES
É parte de: J. Nucl. Med.; (United States), 1985, Vol.26:5
Notas: CONF-850611-
Descrição: Based on the recent report (JNM 25:P15,'84) that cationic /sup 99m/Tc-TMP localized well in animal myocardium, the authors evaluated it for possible clinical use. It was prepared by heating dry /sup 99m/TcO/sub 4/ with 50 mg of TMP in <0.5 ml of methanol or DMSO at 98/sup 0/C for 30'. This reaction also produced 6-10% of an anionic complex impurity (RPTLC, KC/sub 18/F plate, 2% dimethyl phosphite in methanol). This impurity and unreacted TMP were removed by passing the complex through 3x1cm BIOSIL A column and washing with saline. Carrier free /sup 99m/Tc-TMP was eluted with 0.5 ml ethanol, diluted with saline and injected intravenously to rats, rabbits, cats, dogs and rhesus monkey for gamma camera imaging. Excellent myocardial localization was seen in all animals. The quantitative myocardial uptake of /sup 99m/Tc-TMP in rats was comparable to that of /sup 201/Tl. A normal male volunteer was injected with 6.6 mCi of /sup 99m/Tc TMP and gamma camera images were obtained. By 24 hrs, 16% of the injected dose was recovered in the urine. The /sup 99m/Tc-TMP in plasma was not protein bound as determined by gel chromatography and electrophoresis. There seems to be a wide species difference between man and animals in the pharmacokinetics and localization of /sup 99m/Tc-TMP.
Editor: United States
Idioma: Inglês

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An evaluation of /sup 99m/Tc-TMP as a myocardial imaging agent

Jehangir, M. ; Subramanian, G. ; McAfee, J.G. ; Thomas, F.D. ; Gagne, G. ; Zapf-Longo, C. ; Ritter-Hrncirik, C.

United States

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