skip to main content
Visitante
Meu Espaço
Minha Conta
Sair
Identificação
This feature requires javascript
Tags
Revistas Eletrônicas (eJournals)
Livros Eletrônicos (eBooks)
Bases de Dados
Bibliotecas USP
Ajuda
Ajuda
Idioma:
Inglês
Espanhol
Português
This feature required javascript
This feature requires javascript
Primo Search
Busca Geral
Busca Geral
Acervo Físico
Acervo Físico
Produção Intelectual da USP
Produção USP
Search For:
Clear Search Box
Search in:
Busca Geral
Or hit Enter to replace search target
Or select another collection:
Search in:
Busca Geral
Busca Avançada
Busca por Índices
This feature requires javascript
Tipo de recurso
criteria input
qualquer lugar do registro
no título
como autor
no assunto
Data de publicação
lsr01
lsr02
lsr03
lsr04
Orientador
Show Results with:
no título
Show Results with:
qualquer lugar do registro
no título
como autor
no assunto
Data de publicação
lsr01
lsr02
lsr03
lsr04
Orientador
Mostra resultados com:
criteria input
que contêm minhas palavras de busca
com a frase exata
começa com
Mostra resultados com:
Índice
criteria input
E
OU
NÃO
This feature requires javascript
31 Infections in SLE
Navarra, Sandra
Lupus science & medicine, 2022-04, Vol.9 (Suppl 1), p.A17-A17
[Periódico revisado por pares]
London: Lupus Foundation of America
Texto completo disponível
Citações
Citado por
Exibir Online
Detalhes
Resenhas & Tags
Mais Opções
Nº de Citações
This feature requires javascript
Enviar para
Adicionar ao Meu Espaço
Remover do Meu Espaço
E-mail (máximo 30 registros por vez)
Imprimir
Link permanente
Referência
EasyBib
EndNote
RefWorks
del.icio.us
Exportar RIS
Exportar BibTeX
This feature requires javascript
Título:
31 Infections in SLE
Autor:
Navarra, Sandra
Assuntos:
Abstracts
;
Coronaviruses
;
COVID-19 vaccines
;
Disease prevention
;
Disease transmission
;
Hepatitis
;
Lupus
;
Mortality
;
Pathogenesis
;
Pneumonia
;
Rheumatology
;
Streptococcus infections
É parte de:
Lupus science & medicine, 2022-04, Vol.9 (Suppl 1), p.A17-A17
Notas:
11th Annual Meeting of the Lupus Academy, Hybrid meeting held 8–10th April 2022 in Florence, Italy
Plenary III: difficult-to-treat lupus
Descrição:
Infectious agents especially viruses e.g. Epstein Barr virus contribute to systemic lupus erythematosus (SLE) pathogenesis and can trigger lupus disease activity by driving autoimmunity through molecular mimicry, bystander activation and epitope spreading.1 This intricate relationship between viruses and autoimmunity is further substantiated by contemporary observations on the effects of dysregulated host immune response in severe COVID-19 infection resulting in development of autoantibodies and clinical manifestations simulating a lupus flare, albeit with distinguishing features.2Infections are a significant cause of morbidity and mortality in SLE, with infections and active lupus as the most frequent causes of death across various cohorts. Compared with the general population, SLE patients have a median 3-fold increased risk of severe infection and are more likely to die of an infection with standardised mortality ratio (SMR) of 5 specifically due to infections alone.3 The most common infections in SLE are pneumonia and bacterial sepsis, with Staphylococcus aureus, Streptococcus pneumoniae and Escherichia coli as the most common causative agents. There is also a 2.5-fold higher risk of herpes zoster in SLE, and a 6-fold risk of tuberculosis especially in endemic countries. There is a higher incidence of Hepatitis B infection especially in Asia usually triggered by B-cell depleting agents, as well as Pneumocystis jirovecii pneumonia and other opportunistic infections.The susceptibility to infections among lupus patients may be explained by several intrinsic and acquired defects in the immune system. Established risk factors for infection in SLE patients are disease activity including high anti-double-stranded DNA titres, low complement levels, active nephritis, leucopenia, and medications including prednisone or prednisone-equivalent dose greater than 7.5 mg/day, corticosteroid pulse therapy, and high-dose cyclophosphamide.4 Conversely, antimalarials particularly hydroxychloroquine not only control disease activity and prevent flares, but also prevent serious infections in SLE.5 6Although vaccination is essential in the prevention of infections, concerns regarding efficacy (lower immunogenicity and seroprotection), and safety (adverse events or disease flares), among physicians and patients are major deterrents for vaccination. In general, vaccinations against influenza, Streptococcus Pneumonia, Hepatitis A and B, and Human Papilloma Virus are recommended for SLE patients with clear benefit-risk/side-effect profile. Vaccinations should be administered during stable disease and before B cell depletion therapy. Conversely, live vaccines should be avoided in patients on immunosuppressive therapy.ReferencesJames JA, et al. Lupus and Infections. In Dubois Lupus Erythematosus and Related Syndromes. Eds DJ Wallace et al. Saunders Philadelphia 2019. ISBN: 978-0-323-47927-1, pp 543–555.Spihlman AP, Gadi N, Wu SC, Moulton VR. COVID-19 and Systemic Lupus Erythematosus: Focus on Immune Response and Therapeutics. Front Immunol 2020 Oct 30;11:589474. doi: 10.3389/fimmu.2020.589474. PMID: 33193418; PMCID: PMC7661632.Pego-Reigosa JM, Nicholson L, Pooley N, Langham S, Embleton N, Marjenberg Z, Barut V, Desta B, Wang X, Langham J, Hammond ER. The risk of infections in adult patients with systemic lupus erythematosus: systematic review and meta-analysis. Rheumatology (Oxford) 2021 Jan 5;60(1):60–72. doi: 10.1093/rheumatology/keaa478. PMID: 33099651; PMCID: PMC7785308.Ruiz-Irastorza G, Olivares N, Ruiz-Arruza I, Martinez-Berriotxoa A, Egurbide MV, Aguirre C. Predictors of major infections in systemic lupus erythematosus. Arthritis Res Ther 2009;11(4):R109. doi:10.1186/ar2764. Epub 2009 Jul 15. PMID: 19604357; PMCID: PMC2745791.Jung JY, Yoon D, Choi Y, Kim HA, Suh CH. Associated clinical factors for serious infections in patients with systemic lupus erythematosus. Sci Rep 2019 Jul 4;9(1):9704. doi: 10.1038/s41598-019-46039-5. PMID: 31273256; PMCID: PMC6609713.Oku K, Hamijoyo L, Kasitanon N, Li MT, Navarra S, Morand E, Tanaka Y, Mok CC. Prevention of infective complications in systemic lupus erythematosus: A systematic literature review for the APLAR consensus statements. Int J Rheum Dis 2021 Jul;24(7):880–895. doi: 10.1111/1756-185X.14125. Epub 2021 May 17. PMID: 33999518.Learning ObjectivesExplain the role of infections in SLE pathogenesisDescribe the spectrum of infections in SLEDiscuss the risk factors for infectionsDiscuss strategies for prevention of infections in SLE
Editor:
London: Lupus Foundation of America
Idioma:
Inglês
This feature requires javascript
This feature requires javascript
Voltar para lista de resultados
This feature requires javascript
This feature requires javascript
Buscando em bases de dados remotas. Favor aguardar.
Buscando por
em
scope:(USP_VIDEOS),scope:("PRIMO"),scope:(USP_FISICO),scope:(USP_EREVISTAS),scope:(USP),scope:(USP_EBOOKS),scope:(USP_PRODUCAO),primo_central_multiple_fe
Mostrar o que foi encontrado até o momento
This feature requires javascript
This feature requires javascript