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Theranostic Iridium(III) Complexes as One- and Two-Photon Phosphorescent Trackers to Monitor Autophagic Lysosomes

He, Liang ; Tan, Cai-Ping ; Ye, Rui-Rong ; Zhao, Yi-Zhi ; Liu, Ya-Hong ; Zhao, Qiang ; Ji, Liang-Nian ; Mao, Zong-Wan

Angewandte Chemie (International ed.), 2014-11, Vol.53 (45), p.12137-12141 [Periódico revisado por pares]

Weinheim: WILEY-VCH Verlag

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  • Título:
    Theranostic Iridium(III) Complexes as One- and Two-Photon Phosphorescent Trackers to Monitor Autophagic Lysosomes
  • Autor: He, Liang ; Tan, Cai-Ping ; Ye, Rui-Rong ; Zhao, Yi-Zhi ; Liu, Ya-Hong ; Zhao, Qiang ; Ji, Liang-Nian ; Mao, Zong-Wan
  • Assuntos: Autophagy ; bioinorganic chemistry ; Cell Line, Tumor ; Control ; Excitation ; Fluorescence ; Green Fluorescent Proteins - metabolism ; Humans ; Imaging ; iridium ; Iridium - chemistry ; Lysosomes ; Lysosomes - metabolism ; Monitors ; Photons ; probe ; Proton Magnetic Resonance Spectroscopy ; Recycling ; theranostic ; Tracking ; Visualization
  • É parte de: Angewandte Chemie (International ed.), 2014-11, Vol.53 (45), p.12137-12141
  • Notas: 973 Program - No. 2014CB845604
    Fundamental Research Funds for the Central Universities
    Ministry of Education of China - No. IRT1298; No. 313058
    ark:/67375/WNG-VBQ4NH8Q-Q
    This work is supported by the National Natural Science Foundation of China (no. 21172274, 21231007, 21121061, and 21201183), the 973 Program (no. 2014CB845604), the 863 Program (no. 2012AA020305), the Ministry of Education of China (no. IRT1298 and 313058), and the Fundamental Research Funds for the Central Universities. We thank Prof. W.-J. He for his kind assistance in FLIM experiments.
    istex:9B8EEDC89F8801DF3F17AE51C27FF8D831449475
    National Natural Science Foundation of China - No. 21172274; No. 21231007; No. 21121061; No. 21201183
    863 Program - No. 2012AA020305
    ArticleID:ANIE201407468
    This work is supported by the National Natural Science Foundation of China (no. 21172274, 21231007, 21121061, and 21201183), the 973 Program (no. 2014CB845604), the 863 Program (no. 2012AA020305), the Ministry of Education of China (no. IRT1298 and 313058), and the Fundamental Research Funds for the Central Universities. We thank Prof. W.‐J. He for his kind assistance in FLIM experiments.
    ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: During autophagy, the intracellular components are captured in autophagosomes and delivered to lysosomes for degradation and recycling. Changes in lysosomal trafficking and contents are key events in the regulation of autophagy, which has been implicated in many physiological and pathological processes. In this work, two iridium(III) complexes (LysoIr1 and LysoIr2) are developed as theranostic agents to monitor autophagic lysosomes. These complexes display lysosome‐activated phosphorescence and can specifically label lysosomes with high photostability. Simultaneously, they can induce autophagy potently without initiating an apoptosis response. We demonstrate that LysoIr2 can effectively implement two functions, namely autophagy induction and lysosomal tracking, in the visualization of autophagosomal–lysosomal fusion. More importantly, they display strong two‐photon excited fluorescence (TPEF), which is favorable for live cell imaging and in vivo applications. Kill Two Birds with One Stone: Two iridium(III) complexes can specifically image lysosomes and induce an autophagic response in live cells. The combination of these two intriguing properties makes them ideal theranostic agents to track lysosomal changes during autophagic processes. Additionally, these complexes display strong two‐photon excited fluorescence, which is favorable for live cell imaging and in vivo applications.
  • Editor: Weinheim: WILEY-VCH Verlag
  • Idioma: Inglês
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