skip to main content
Idioma:
Primo Search
Clear Search Box
Search in: Busca Geral
Busca Avançada
Busca por Índices

Recent Advances in Nanostrategies Capable of Overcoming Biological Barriers for Tumor Management

Huo, Da ; Jiang, Xiqun ; Hu, Yong

Advanced materials (Weinheim), 2020-07, Vol.32 (27), p.e1904337-n/a [Periódico revisado por pares]

Germany: Wiley Subscription Services, Inc

Texto completo disponível

Citações Citado por
  • Título:
    Recent Advances in Nanostrategies Capable of Overcoming Biological Barriers for Tumor Management
  • Autor: Huo, Da ; Jiang, Xiqun ; Hu, Yong
  • Assuntos: Apoptosis ; Barriers ; deep penetration ; drug delivery ; Efflux ; Hypoxia ; Nanomaterials ; nanomedicine ; on‐demand release ; tumor microenvironment ; Tumors
  • É parte de: Advanced materials (Weinheim), 2020-07, Vol.32 (27), p.e1904337-n/a
  • Descrição: Engineered nanomaterials have been extensively employed as therapeutics for tumor management. Meanwhile, the complex tumor niche along with multiple barriers at the cellular level collectively hinders the action of nanomedicines. Here, the advanced strategies that hold promise for overcoming the numerous biological barriers facing nanomedicines are summarized. Starting from tumor entry, methods that promote tissue penetration of nanomedicine and address the hypoxia issue are also highlighted. Then, emphasis is given to the significance of overcoming both physical barriers, such as membrane‐associated efflux pumps, and biological features, such as resistance to apoptosis. The pros and cons for an individual approach are presented. In addition, the associated technical problems are discussed, along with the importance of balancing the therapeutic merits and the additional cost of sophisticated nanomedicine designs. The emergence of nanomedicine provides a promising means to conquer cancer. The progress in approaches designed to bypass various biological barriers that nanomedicines might face before fulfilling their antitumoral purpose is highlighted. Discussions are provided following the sequence of barriers emerged in vivo, with both pros and cons emphasized for any individual strategies.
  • Editor: Germany: Wiley Subscription Services, Inc
  • Idioma: Inglês
Links
Voltar para lista de resultados

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.