Idioma:

Measles-mumps-rubella-varicella combination vaccine and the risk of febrile seizures

Klein, Nicola P ; Fireman, Bruce ; Yih, W Katherine ; Lewis, Edwin ; Kulldorff, Martin ; Ray, Paula ; Baxter, Roger ; Hambidge, Simon ; Nordin, James ; Naleway, Allison ; Belongia, Edward A ; Lieu, Tracy ; Baggs, James ; Weintraub, Eric

Pediatrics (Evanston), 2010-07, Vol.126 (1), p.e1-e8 [Periódico revisado por pares]

United States: American Academy of Pediatrics

Texto completo disponível

Citações Citado por

Enviar para

Título:
Measles-mumps-rubella-varicella combination vaccine and the risk of febrile seizures
Autor: Klein, Nicola P ; Fireman, Bruce ; Yih, W Katherine ; Lewis, Edwin ; Kulldorff, Martin ; Ray, Paula ; Baxter, Roger ; Hambidge, Simon ; Nordin, James ; Naleway, Allison ; Belongia, Edward A ; Lieu, Tracy ; Baggs, James ; Weintraub, Eric
Assuntos: Age Distribution ; Chicken pox ; Chickenpox Vaccine - administration & dosage ; Chickenpox Vaccine - adverse effects ; Cohort Studies ; Convulsions & seizures ; Databases, Factual ; Female ; Follow-Up Studies ; Humans ; Immunization ; Incidence ; Infant ; Male ; Measles ; Measles-Mumps-Rubella Vaccine - administration & dosage ; Measles-Mumps-Rubella Vaccine - adverse effects ; Mumps ; Pediatrics ; Retrospective Studies ; Seizures, Febrile - chemically induced ; Seizures, Febrile - epidemiology ; Seizures, Febrile - physiopathology ; Severity of Illness Index ; Sex Distribution ; Time Factors ; Vaccination - adverse effects ; Vaccination - methods ; Vaccines ; Vaccines, Combined - administration & dosage ; Vaccines, Combined - adverse effects
É parte de: Pediatrics (Evanston), 2010-07, Vol.126 (1), p.e1-e8
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: In February 2008, we alerted the Advisory Committee on Immunization Practices to preliminary evidence of a twofold increased risk of febrile seizures after the combination measles-mumps-rubella-varicella (MMRV) vaccine when compared with separate measles-mumps-rubella (MMR) and varicella vaccines. Now with data on twice as many vaccine recipients, our goal was to reexamine seizure risk after MMRV vaccine. Using 2000-2008 Vaccine Safety Datalink data, we assessed seizures and fever visits among children aged 12 to 23 months after MMRV and separate MMR + varicella vaccines. We compared seizure risk after MMRV vaccine to that after MMR + varicella vaccines by using Poisson regression as well as with supplementary regressions that incorporated chart-review results and self-controlled analyses. MMRV vaccine recipients (83,107) were compared with recipients of MMR + varicella vaccines (376,354). Seizure and fever significantly clustered 7 to 10 days after vaccination with all measles-containing vaccines but not after varicella vaccination alone. Seizure risk during days 7 to 10 was higher after MMRV than after MMR + varicella vaccination (relative risk: 1.98 [95% confidence interval: 1.43-2.73]). Supplementary analyses yielded similar results. The excess risk for febrile seizures 7 to 10 days after MMRV compared with separate MMR + varicella vaccination was 4.3 per 10,000 doses (95% confidence interval: 2.6-5.6). Among 12- to 23-month-olds who received their first dose of measles-containing vaccine, fever and seizure were elevated 7 to 10 days after vaccination. Vaccination with MMRV results in 1 additional febrile seizure for every 2300 doses given instead of separate MMR + varicella vaccines. Providers who recommend MMRV should communicate to parents that it increases the risk of fever and seizure over that already associated with measles-containing vaccines.
Editor: United States: American Academy of Pediatrics
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Measles-mumps-rubella-varicella combination vaccine and the risk of febrile seizures

Klein, Nicola P ; Fireman, Bruce ; Yih, W Katherine ; Lewis, Edwin ; Kulldorff, Martin ; Ray, Paula ; Baxter, Roger ; Hambidge, Simon ; Nordin, James ; Naleway, Allison ; Belongia, Edward A ; Lieu, Tracy ; Baggs, James ; Weintraub, Eric

United States: American Academy of Pediatrics

Buscando em bases de dados remotas. Favor aguardar.