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Dynamic coupling of pattern formation and morphogenesis in the developing vertebrate retina

Picker, Alexander ; Cavodeassi, Florencia ; Machate, Anja ; Bernauer, Sabine ; Hans, Stefan ; Abe, Gembu ; Kawakami, Koichi ; Wilson, Stephen W ; Brand, Michael Harris, William A.

PLoS biology, 2009-10, Vol.7 (10), p.e1000214-e1000214 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Dynamic coupling of pattern formation and morphogenesis in the developing vertebrate retina
Autor: Picker, Alexander ; Cavodeassi, Florencia ; Machate, Anja ; Bernauer, Sabine ; Hans, Stefan ; Abe, Gembu ; Kawakami, Koichi ; Wilson, Stephen W ; Brand, Michael
Harris, William A.
Assuntos: Animals ; Body Patterning - physiology ; Cell Biology/Cell Adhesion ; Cell Biology/Cell Signaling ; Cell Biology/Developmental Molecular Mechanisms ; Cell Biology/Gene Expression ; Cell Biology/Morphogenesis and Cell Biology ; Cellular biology ; Developmental Biology/Developmental Molecular Mechanisms ; Developmental Biology/Embryology ; Developmental Biology/Molecular Development ; Developmental Biology/Morphogenesis and Cell Biology ; Developmental Biology/Neurodevelopment ; Developmental Biology/Pattern Formation ; Embryo, Nonmammalian - embryology ; Embryos ; Female ; Fibroblast Growth Factor 3 - physiology ; Fibroblast Growth Factors - physiology ; Forkhead Transcription Factors - physiology ; Genetics and Genomics/Animal Genetics ; Neuroscience/Neurodevelopment ; Neuroscience/Sensory Systems ; Retina ; Retina - embryology ; Signal Transduction - physiology ; Zebrafish ; Zebrafish Proteins - physiology
É parte de: PLoS biology, 2009-10, Vol.7 (10), p.e1000214-e1000214
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: AP FC SB SWW MB. Performed the experiments: AP FC AM SB. Analyzed the data: AP FC SB. Contributed reagents/materials/analysis tools: AP FC SB SH GA KK SWW MB. Wrote the paper: AP FC SWW MB.
Descrição: During embryonic development, pattern formation must be tightly synchronized with tissue morphogenesis to coordinate the establishment of the spatial identities of cells with their movements. In the vertebrate retina, patterning along the dorsal-ventral and nasal-temporal (anterior-posterior) axes is required for correct spatial representation in the retinotectal map. However, it is unknown how specification of axial cell positions in the retina occurs during the complex process of early eye morphogenesis. Studying zebrafish embryos, we show that morphogenetic tissue rearrangements during eye evagination result in progenitor cells in the nasal half of the retina primordium being brought into proximity to the sources of three fibroblast growth factors, Fgf8/3/24, outside the eye. Triple-mutant analysis shows that this combined Fgf signal fully controls nasal retina identity by regulating the nasal transcription factor Foxg1. Surprisingly, nasal-temporal axis specification occurs very early along the dorsal-ventral axis of the evaginating eye. By in vivo imaging GFP-tagged retinal progenitor cells, we find that subsequent eye morphogenesis requires gradual tissue compaction in the nasal half and directed cell movements into the temporal half of the retina. Balancing these processes drives the progressive alignment of the nasal-temporal retina axis with the anterior-posterior body axis and is controlled by a feed-forward effect of Fgf signaling on Foxg1-mediated cell cohesion. Thus, the mechanistic coupling and dynamic synchronization of tissue patterning with morphogenetic cell behavior through Fgf signaling leads to the graded allocation of cell positional identity in the eye, underlying retinotectal map formation.
Editor: United States: Public Library of Science
Idioma: Inglês

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Dynamic coupling of pattern formation and morphogenesis in the developing vertebrate retina

Picker, Alexander ; Cavodeassi, Florencia ; Machate, Anja ; Bernauer, Sabine ; Hans, Stefan ; Abe, Gembu ; Kawakami, Koichi ; Wilson, Stephen W ; Brand, Michael Harris, William A.

United States: Public Library of Science

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