Humoral response of Meriones libycus to experimental infection with Leishmania major

• Autor: AL-YOUNES, E. K. SALIBA, M. AL-KHAT, H.
• Assuntos: Leishmania major ; Meriones libycus
• É parte de: Annals of tropical medicine and parasitology, 1999-04, Vol.93 (3), p.239-245
• Notas: ObjectType-Article-2
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• Descrição: The humoral responses of laboratory-reared jirds (Meriones libycus) to inoculation with various doses of Leishmania major were determined. The animals were inoculated intradermally with 10 super(2), 10 super(3), 10 super(5) or 10 super(7) promastigotes of a strain of L. major originally isolated from a Jordanian patient. The jirds were then bled at various intervals throughout the 26 weeks of the study, and the sera checked, by IFAT, for antibodies to homologous parasites. There were no detectable humoral responses in the animals inoculated with 10 super(2) promastigotes each or in parasite-free controls but a positive response was apparent in each of the other jirds. The animals given 10 super(3) promastigotes each required 3 months to become IFAT-positive whereas those given 10 super(5) and 10 super(7) parasites only needed 4 and 2 weeks, respectively. More than 50% of the animals inoculated with 10 super(3) parasites each developed strongly positive sera 2 months post-infection, whereas >50% of the animals inoculated with 10 super(5) or 10 super(7) parasites each had strongly or very strongly positive sera 4 and 2 weeks post-inoculation, respectively. The data indicate that, in M. libycus inoculated with L. major, the time required for the humoral response to develop and its intensity are both dose-related.
  
• Idioma: Inglês