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Reduced lung function and health-related quality of life after treatment for pulmonary tuberculosis in Gambian children: a cross-sectional comparative study

Nkereuwem, Esin ; Agbla, Schadrac ; Sallahdeen, Azeezat ; Owolabi, Olumuyiwa ; Sillah, Abdou K ; Genekah, Monica ; Tunkara, Abdoulie ; Kandeh, Sheriff ; Jawara, Maryama ; Saidy, Lamin ; Bush, Andrew ; Togun, Toyin ; Kampmann, Beate

Thorax, 2023-03, Vol.78 (3), p.281-287 [Periódico revisado por pares]

England: BMJ Publishing Group Ltd and British Thoracic Society

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Título:
Reduced lung function and health-related quality of life after treatment for pulmonary tuberculosis in Gambian children: a cross-sectional comparative study
Autor: Nkereuwem, Esin ; Agbla, Schadrac ; Sallahdeen, Azeezat ; Owolabi, Olumuyiwa ; Sillah, Abdou K ; Genekah, Monica ; Tunkara, Abdoulie ; Kandeh, Sheriff ; Jawara, Maryama ; Saidy, Lamin ; Bush, Andrew ; Togun, Toyin ; Kampmann, Beate
Assuntos: Adolescent ; Adults ; Age ; Child ; Clinical Epidemiology ; Contact tracing ; Cross-Sectional Studies ; Forced Expiratory Volume ; Gambia ; Households ; Humans ; Longitudinal studies ; Lung ; Lung diseases ; Lungs ; Medical research ; Paediatric Lung Disaese ; Quality of Life ; Respiratory Infection ; Spirometry ; Thorax ; Tuberculosis ; Tuberculosis, Pulmonary - complications ; Vital Capacity
É parte de: Thorax, 2023-03, Vol.78 (3), p.281-287
Notas: Original research
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: BackgroundPost-tuberculosis (post-TB) lung disease is an under-recognised consequence of pulmonary tuberculosis (pTB). We aimed to estimate the prevalence of residual lung function impairment and reduced health-related quality of life (HRQoL) in children after pTB treatment completion.MethodsWe conducted a cross-sectional comparative study of children aged less than 15 years at TB diagnosis who had completed treatment for pTB at least 6 months previously with a comparator group of age-matched children without a history of pTB. Symptoms, spirometry and HRQoL measured with PedsQL scale were collected. Variables associated with lung function impairment were identified through logistic regression models.ResultsWe enrolled 68 post-TB cases (median age 8.9 (IQR 7.2–11.2) years) and 91 children in the comparison group (11.5 (8.0–13.7) years). Spirometry from 52 (76.5%) post-TB cases and 89 (94.5%) of the comparison group met the quality criteria for acceptability and repeatability. Lung function impairment was present in 20/52 (38.5%) post-TB cases and 15/86 (17.4%) in the comparison group, p=0.009. Previous pTB and a history of chronic cough were significantly associated with the presence of lung function impairment (p=0.047 and 0.006 respectively). Forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC z-scores were significantly lower in the post-TB cases compared with the comparison group (p= <0.001, 0.014 and <0.001, respectively). The distribution of the self-reported physical health score, and parent-reported physical, emotional, psychological, social and total HRQoL scores were significantly lower in the post-TB cases compared with the comparison group.ConclusionsPrevious TB in children is associated with significantly impaired lung function and HRQoL.
Editor: England: BMJ Publishing Group Ltd and British Thoracic Society
Idioma: Inglês

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Reduced lung function and health-related quality of life after treatment for pulmonary tuberculosis in Gambian children: a cross-sectional comparative study

Nkereuwem, Esin ; Agbla, Schadrac ; Sallahdeen, Azeezat ; Owolabi, Olumuyiwa ; Sillah, Abdou K ; Genekah, Monica ; Tunkara, Abdoulie ; Kandeh, Sheriff ; Jawara, Maryama ; Saidy, Lamin ; Bush, Andrew ; Togun, Toyin ; Kampmann, Beate

England: BMJ Publishing Group Ltd and British Thoracic Society

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