Idioma:

Overexpression of mouse angiotensinogen in renal proximal tubule causes salt-sensitive hypertension in mice

Ying, Jian ; Stuart, Deborah ; Hillas, Elaine ; Gociman, Barbu R ; Ramkumar, Nirupama ; Lalouel, Jean-Marc ; Kohan, Donald E

American journal of hypertension, 2012-06, Vol.25 (6), p.684-689 [Periódico revisado por pares]

Basingstoke: Oxford University Press

Texto completo disponível

Citações Citado por

Enviar para

Título:
Overexpression of mouse angiotensinogen in renal proximal tubule causes salt-sensitive hypertension in mice
Autor: Ying, Jian ; Stuart, Deborah ; Hillas, Elaine ; Gociman, Barbu R ; Ramkumar, Nirupama ; Lalouel, Jean-Marc ; Kohan, Donald E
Assuntos: Angiotensinogen - genetics ; Angiotensinogen - metabolism ; Animals ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Pressure - drug effects ; Blood Pressure - physiology ; Cardiology. Vascular system ; Chimera - genetics ; Clinical manifestations. Epidemiology. Investigative techniques. Etiology ; Disease Models, Animal ; Female ; Gene Knock-In Techniques ; Hypertension - chemically induced ; Hypertension - metabolism ; Hypertension - physiopathology ; Kidney Tubules, Proximal - metabolism ; Male ; Medical sciences ; Mice ; Mice, Inbred C57BL ; Renin - blood ; Renin-Angiotensin System - physiology ; RNA, Messenger - metabolism ; Sodium Chloride, Dietary - adverse effects ; Sodium Chloride, Dietary - pharmacology
É parte de: American journal of hypertension, 2012-06, Vol.25 (6), p.684-689
Descrição: Background The role of proximal tubule (PT) angiotensinogen (AGT) in modulating blood pressure has previously been examined using mice expressing PT human AGT and human renin, or rat AGT. These animals are hypertensive; however, the question remains whether alterations in mouse PT AGT alone affects arterial pressure. Methods Mouse AGT cDNA was knocked-in to the endogenous kidney androgen protein (KAP) gene using an internal ribosomal entry site (IRES)-based strategy. Results The KAP-mAGT animals showed kidney-specific KAP-AGT mRNA expression; renal in situ hybridization detected KAP-AGT mRNA only in PT. Urinary AGT was markedly increased in KAP-mAGT mice. On a high Na diet, radiotelemetric arterial pressure showed a systolic pressure elevation; no significant difference in arterial pressure was observed on a normal diet. Plasma renin concentration (PRC) was reduced in KAP-mAGT animals given a high Na diet, but was not different between mouse lines during normal Na intake. Plasma AGT concentration was not altered by overexpression of PT mouse AGT. Conclusions In summary, PT overexpression of mouse AGT leads to salt-sensitive hypertension without recruitment of the systemic renin-angiotensin system.
Editor: Basingstoke: Oxford University Press
Idioma: Inglês

Links

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Overexpression of mouse angiotensinogen in renal proximal tubule causes salt-sensitive hypertension in mice

Ying, Jian ; Stuart, Deborah ; Hillas, Elaine ; Gociman, Barbu R ; Ramkumar, Nirupama ; Lalouel, Jean-Marc ; Kohan, Donald E

Basingstoke: Oxford University Press

Buscando em bases de dados remotas. Favor aguardar.