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Microsatellite characterization of Plasmodium falciparum from symptomatic and non-symptomatic infections from the Western Amazon reveals the existence of non-symptomatic infection-associated genotypes

Martha, Rosimeire Cristina dalla ; Tada, Mauro Sughiro ; de Mattos Ferreira, Ricardo Godoi ; da Silva, Luiz Hildebrando Pereira ; Wunderlich, Gerhard

Memórias do Instituto Oswaldo Cruz, 2007-06, Vol.102 (3), p.293-298 [Periódico revisado por pares]

Brazil: Fundação Oswaldo Cruz, Fiocruz

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Título:
Microsatellite characterization of Plasmodium falciparum from symptomatic and non-symptomatic infections from the Western Amazon reveals the existence of non-symptomatic infection-associated genotypes
Autor: Martha, Rosimeire Cristina dalla ; Tada, Mauro Sughiro ; de Mattos Ferreira, Ricardo Godoi ; da Silva, Luiz Hildebrando Pereira ; Wunderlich, Gerhard
Assuntos: Alleles ; Animals ; Brazil ; DNA, Protozoan - genetics ; Genetic Markers ; Genotype ; genotyping ; Humans ; Malaria, Falciparum - parasitology ; Microsatellite Repeats - genetics ; microsatellites ; microsatellites - genotyping ; non-symptomatic malaria ; PARASITOLOGY ; Plasmodium falciparum ; Plasmodium falciparum - genetics ; Polymerase Chain Reaction ; Risk Factors ; TROPICAL MEDICINE
É parte de: Memórias do Instituto Oswaldo Cruz, 2007-06, Vol.102 (3), p.293-298
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: In Western Amazon areas with perennial malaria transmission, long term residents frequently develop partial immunity to malarial infection caused either by Plasmodium falciparum or P. vivax, resulting in a considerable number of non-symptomatically infected individuals. For yet unknown reasons, these individuals sporadically develop symptomatic malaria. In order to identify if determined parasite genotypes, defined by a combination of eleven microsatellite markers, were associated to different outcomes symptomatic or asymptomatic malaria we analyzed infecting P. falciparum parasites in a suburban riverine population. Despite of detecting a high degree of diversity in the analyzed samples, several microsatellite marker alleles appeared accumulated in parasites from non-symptomatic infections. This result may be interpreted that a number of microsatellites, which are not directly related to antigenic features, could be associated to the outcome of malarial infection. The result may also point to a low frequency of recombinatorial events which otherwise would dissociate genes under strong immune pressure from the relatively neutral microsatellite loci.
Editor: Brazil: Fundação Oswaldo Cruz, Fiocruz
Idioma: Inglês;Português

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Microsatellite characterization of Plasmodium falciparum from symptomatic and non-symptomatic infections from the Western Amazon reveals the existence of non-symptomatic infection-associated genotypes

Martha, Rosimeire Cristina dalla ; Tada, Mauro Sughiro ; de Mattos Ferreira, Ricardo Godoi ; da Silva, Luiz Hildebrando Pereira ; Wunderlich, Gerhard

Brazil: Fundação Oswaldo Cruz, Fiocruz

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