Idioma:

IL17 Promotes Mammary Tumor Progression by Changing the Behavior of Tumor Cells and Eliciting Tumorigenic Neutrophils Recruitment

Benevides, Luciana ; da Fonseca, Denise Morais ; Donate, Paula Barbim ; Tiezzi, Daniel Guimarães ; De Carvalho, Daniel D ; de Andrade, Jurandyr M ; Martins, Gislaine A ; Silva, João S

Cancer research (Chicago, Ill.), 2015-09, Vol.75 (18), p.3788-3799 [Periódico revisado por pares]

United States

Texto completo disponível

Citações Citado por

Enviar para

Título:
IL17 Promotes Mammary Tumor Progression by Changing the Behavior of Tumor Cells and Eliciting Tumorigenic Neutrophils Recruitment
Autor: Benevides, Luciana ; da Fonseca, Denise Morais ; Donate, Paula Barbim ; Tiezzi, Daniel Guimarães ; De Carvalho, Daniel D ; de Andrade, Jurandyr M ; Martins, Gislaine A ; Silva, João S
Assuntos: Animals ; Breast Neoplasms - chemistry ; Breast Neoplasms - immunology ; Breast Neoplasms - mortality ; Breast Neoplasms - pathology ; Carcinoma, Ductal, Breast - chemistry ; Carcinoma, Ductal, Breast - immunology ; Carcinoma, Ductal, Breast - mortality ; Carcinoma, Ductal, Breast - secondary ; Chemotaxis, Leukocyte - physiology ; Cytokines - biosynthesis ; Cytokines - genetics ; Cytokines - metabolism ; Disease Progression ; Disease-Free Survival ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Humans ; Interleukin-17 - analysis ; Interleukin-17 - antagonists & inhibitors ; Interleukin-17 - immunology ; Interleukin-17 - physiology ; Lymphocytes, Tumor-Infiltrating - immunology ; Lymphocytes, Tumor-Infiltrating - metabolism ; Mammary Neoplasms, Experimental - immunology ; Mammary Neoplasms, Experimental - pathology ; Mice ; Mice, Inbred BALB C ; Neoplasm Proteins - analysis ; Neoplasm Proteins - antagonists & inhibitors ; Neoplasm Proteins - immunology ; Neoplasm Proteins - physiology ; Neutrophils - immunology ; Neutrophils - metabolism ; Prognosis ; Th17 Cells - immunology
É parte de: Cancer research (Chicago, Ill.), 2015-09, Vol.75 (18), p.3788-3799
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
Descrição: The aggressiveness of invasive ductal carcinoma (IDC) of the breast is associated with increased IL17 levels. Studying the role of IL17 in invasive breast tumor pathogenesis, we found that metastatic primary tumor-infiltrating T lymphocytes produced elevated levels of IL17, whereas IL17 neutralization inhibited tumor growth and prevented the migration of neutrophils and tumor cells to secondary disease sites. Tumorigenic neutrophils promote disease progression, producing CXCL1, MMP9, VEGF, and TNFα, and their depletion suppressed tumor growth. IL17A also induced IL6 and CCL20 production in metastatic tumor cells, favoring the recruitment and differentiation of Th17. In addition, IL17A changed the gene-expression profile and the behavior of nonmetastatic tumor cells, causing tumor growth in vivo, confirming the protumor role of IL17. Furthermore, high IL17 expression was associated with lower disease-free survival and worse prognosis in IDC patients. Thus, IL17 blockade represents an attractive approach for the control of invasive breast tumors.
Editor: United States
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

IL17 Promotes Mammary Tumor Progression by Changing the Behavior of Tumor Cells and Eliciting Tumorigenic Neutrophils Recruitment

Benevides, Luciana ; da Fonseca, Denise Morais ; Donate, Paula Barbim ; Tiezzi, Daniel Guimarães ; De Carvalho, Daniel D ; de Andrade, Jurandyr M ; Martins, Gislaine A ; Silva, João S

United States

Buscando em bases de dados remotas. Favor aguardar.