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Nutritional anemia and megaloblastosis in pregnancy
Lowenstein, L ; Brunton, L ; Hsieh, Y S
Canadian Medical Association journal, 1966-03, Vol.94 (13), p.636-645
[Periódico revisado por pares]
Canada
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Título:
Nutritional anemia and megaloblastosis in pregnancy
Autor:
Lowenstein, L
;
Brunton, L
;
Hsieh, Y S
Assuntos:
Anemia, Hypochromic - complications
;
Female
;
Folic Acid - therapeutic use
;
Folic Acid Deficiency - complications
;
Humans
;
In Vitro Techniques
;
Original
;
Pregnancy
;
Pregnancy Complications, Hematologic
;
Vitamin B 12 - therapeutic use
;
Vitamin B 12 Deficiency - complications
É parte de:
Canadian Medical Association journal, 1966-03, Vol.94 (13), p.636-645
Notas:
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição:
Macrogranulocytic and/or erythroid megaloblastic bone marrow changes which could not be accurately predicted from the hematologic findings in the blood were present in 25% of 305 mildly to moderately anemic pregnant women attending a public antepartum clinic in Montreal. Iron deficiency was the primary cause of anemia in most instances. Serum folate activity of less than 4.1 ng./ml. and/or serum vitamin B(12) levels of less than 100 pg./ml. were present in 90% of the 77 patients having these bone marrow changes, whereas approximately one-third of 228 patients with normoblastic marrow had these low values. Red cell folate did not correlate as well as serum folate activity with bone marrow changes. After treatment with oral folic acid in the range of 0.2 mg. to 0.8 mg., daily, for seven to 14 days, the megaloblastic and macrogranulocytic changes in patients with low serum folate activity and normal serum vitamin B(12) values disappeared in 15 of 21 patients. Of five women having both low folate and vitamin B(12) values, three failed to respond and two showed only partial improvement after 0.4 mg. of folic acid daily, per os, for 10 days. The average diet of these anemic women was suboptimal in folate and in iron.
Editor:
Canada
Idioma:
Inglês
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