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Expression of microRNA-1234 related signal transducer and activator of transcription 3 in patients with diffuse large B-cell lymphoma of activated B-cell like type from high and low infectious disease areas

Högfeldt, Therese ; Johnsson, Per ; Grandér, Dan ; Bahnassy, Abeer A. ; Porwit, Anna ; Eid, Salem ; Österborg, Anders ; Zekri, Abdel-Rahman N. ; Lundahl, Joachim ; Khaled, Mustafa Hussein ; Mellstedt, Håkan ; Moshfegh, Ali

Leukemia & lymphoma, 2014-05, Vol.55 (5), p.1158-1165 [Periódico revisado por pares]

United States: Informa Healthcare

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Expression of microRNA-1234 related signal transducer and activator of transcription 3 in patients with diffuse large B-cell lymphoma of activated B-cell like type from high and low infectious disease areas
Autor: Högfeldt, Therese ; Johnsson, Per ; Grandér, Dan ; Bahnassy, Abeer A. ; Porwit, Anna ; Eid, Salem ; Österborg, Anders ; Zekri, Abdel-Rahman N. ; Lundahl, Joachim ; Khaled, Mustafa Hussein ; Mellstedt, Håkan ; Moshfegh, Ali
Assuntos: Adult ; Aged ; Case-Control Studies ; Cell Line ; Cluster Analysis ; DLBCL ; Egypt ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Lymphoma, Large B-Cell, Diffuse - drug therapy ; Lymphoma, Large B-Cell, Diffuse - genetics ; Lymphoma, Large B-Cell, Diffuse - metabolism ; Lymphoma, Large B-Cell, Diffuse - mortality ; Male ; Medicin och hälsovetenskap ; MicroRNAs - genetics ; Middle Aged ; miRNA ; RNA Interference ; STAT3 ; STAT3 Transcription Factor - genetics ; STAT3 Transcription Factor - metabolism ; Sweden ; Transcriptome ; Transfection
É parte de: Leukemia & lymphoma, 2014-05, Vol.55 (5), p.1158-1165
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SourceType-Scholarly Journals-1
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Descrição: Abstract Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease, and infectious agents are suspected to be involved in the tumorigenesis of DLBCL. MicroRNAs (miRNAs) are non-coding RNAs modulating protein expression. We compared miRNA expression profiles in lymph node tissues of patients with DLBCL of the activated B-cell like (ABC) type from two geographical areas with different background exposures, Sweden and Egypt. We showed previously that DLBCL tissues of the ABC-type in Swedish patients had a higher expression of signal transducer and activator of transcription 3 (STAT3) compared to Egyptian patients. Here, we analyzed the involvement of miRNAs in STAT3 regulation. miR-1234 was significantly up-regulated in Egyptian patients with DLBCL compared to Swedish patients (p < 0.03). The miR-1234 expression level correlated inversely with the expression of STAT3. The Stat3 protein was down-regulated in cells transfected with miR-1234, suggesting that STAT3 might be a potential target for miR-1234. miR-1234 and STAT3 might be involved in the tumorigenesis of DLBCL of ABC type and possibly associated with environmental background exposure.
Editor: United States: Informa Healthcare
Idioma: Inglês

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Expression of microRNA-1234 related signal transducer and activator of transcription 3 in patients with diffuse large B-cell lymphoma of activated B-cell like type from high and low infectious disease areas

Högfeldt, Therese ; Johnsson, Per ; Grandér, Dan ; Bahnassy, Abeer A. ; Porwit, Anna ; Eid, Salem ; Österborg, Anders ; Zekri, Abdel-Rahman N. ; Lundahl, Joachim ; Khaled, Mustafa Hussein ; Mellstedt, Håkan ; Moshfegh, Ali

United States: Informa Healthcare

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