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The decrease of erythrocyte catechol-O-methyltransferase activity in depressed patients and its diagnostic significance

Karege, F. ; Bovier, P. ; Gaillard, J.-M. ; Tissot, R.

Acta psychiatrica Scandinavica, 1987-09, Vol.76 (3), p.303-308 [Periódico revisado por pares]

Oxford, UK: Blackwell Publishing Ltd

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Título:
The decrease of erythrocyte catechol-O-methyltransferase activity in depressed patients and its diagnostic significance
Autor: Karege, F. ; Bovier, P. ; Gaillard, J.-M. ; Tissot, R.
Assuntos: Adult ; affective disorder ; Biological and medical sciences ; Bipolar Disorder - enzymology ; Catechol O-Methyltransferase - blood ; catechol-O-methyltransferase ; depression ; Depressive Disorder - diagnosis ; Depressive Disorder - enzymology ; Depressive Disorder - genetics ; erythrocyte ; Erythrocytes - enzymology ; Female ; Genetic Markers ; Humans ; Male ; Medical sciences ; Middle Aged ; Miscellaneous ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Recurrence ; Techniques and methods
É parte de: Acta psychiatrica Scandinavica, 1987-09, Vol.76 (3), p.303-308
Notas: ArticleID:ACPS303
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ark:/67375/WNG-D83GGVD0-P
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Erythrocyte catechol‐O‐methyltransferase (COMT) activity was measured in normal and depressed populations before specific medication. In the groups of patients, anxiety and depression scores were evaluated by the AMDP rating scale. The authors found lower enzyme activity in patients with major depression, recurrent and bipolar disorder, depressed, but no change was found in dysthymic disorder when compared to control values. However, there was no relationship between COMT activity and age, anxiety and depression scores of patients. Furthermore, the subdivision into two subpopulations, one with normal COMT activity and another with lower COMT activity, did not make it possible to assign a role to the enzyme in the severity of depression. The enzyme could, however, be considered as a genetic marker of depressive vulnerability.
Editor: Oxford, UK: Blackwell Publishing Ltd
Idioma: Inglês

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The decrease of erythrocyte catechol-O-methyltransferase activity in depressed patients and its diagnostic significance

Karege, F. ; Bovier, P. ; Gaillard, J.-M. ; Tissot, R.

Oxford, UK: Blackwell Publishing Ltd

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