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Immunopsychiatry: important facts

Khandaker, G. M. ; Dantzer, R. ; Jones, P. B.

Psychological medicine, 2017-10, Vol.47 (13), p.2229-2237 [Periódico revisado por pares]

Cambridge, UK: Cambridge University Press

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Título:
Immunopsychiatry: important facts
Autor: Khandaker, G. M. ; Dantzer, R. ; Jones, P. B.
Assuntos: Adults ; Autoimmunity ; Autoimmunity - immunology ; Behavior disorders ; Brain research ; Clinical research ; Coronary artery disease ; Coronary diseases ; Cytokines ; Cytomegalovirus ; Depressive Disorder - drug therapy ; Depressive Disorder - etiology ; Depressive Disorder - immunology ; Diabetes mellitus ; Disorders ; Etiology ; Heart diseases ; Humans ; Illnesses ; Immune response system ; Immune system ; Immunoglobulins ; Immunomodulation ; Immunotherapy - methods ; Infections ; Inflammation ; Inflammation - complications ; Inflammation - drug therapy ; Medical personnel ; Mental depression ; Mental disorders ; Psychiatrists ; Psychiatry ; Psychoses ; Psychosis ; Psychotropic drugs ; Schizophrenia ; Schizophrenia - drug therapy ; Schizophrenia - etiology ; Schizophrenia - immunology ; Short Teaching ; Short Teaching Article ; Tumor necrosis factor-TNF
É parte de: Psychological medicine, 2017-10, Vol.47 (13), p.2229-2237
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
Descrição: Accumulating evidence indicate a role for the immune system particularly inflammation and autoimmunity in the aetiology of major psychiatric disorders such as depression and schizophrenia. In this paper, we discuss some of the key advances in immunopsychiatry in order to highlight to psychiatrists and other health professionals how an increased understanding of this field might enhance our knowledge of illness mechanism and approaches to treatment. We present a brief overview of clinical research that link inflammation and autoimmunity with depression and psychosis, including potential role of inflammation in treatment response, current evidence for the effectiveness of immune-modulating treatment for depression and psychosis, and possible role of inflammation in common physical comorbidities for these disorders such as coronary heart disease and diabetes mellitus. Gaining a better understanding of the role of immune system could be paradigm changing for psychiatry. We need collaborations between clinicians and scientists to deliver high-quality translational research in order to fully realise the clinical potential of this exciting and rapidly expanding field.
Editor: Cambridge, UK: Cambridge University Press
Idioma: Inglês

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Immunopsychiatry: important facts

Khandaker, G. M. ; Dantzer, R. ; Jones, P. B.

Cambridge, UK: Cambridge University Press

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