Idioma:

Mosaic expression of brush-border enzymes in infants with chronic diarrhea and malnutrition

Nichols, B.L. (Children's Nutrition Research Center, Houston, TX) ; Carrazza, F ; Nichols, V.N ; Putman, M ; Johnston, P ; Rodrigues, M ; Quaroni, A ; Shiner, M

Journal of pediatric gastroenterology and nutrition, 1992-05, Vol.14 (4), p.371-379 [Periódico revisado por pares]

PHILADELPHIA: Lippincott-Raven Publishers

Texto completo disponível

Citações Citado por

Enviar para

Título:
Mosaic expression of brush-border enzymes in infants with chronic diarrhea and malnutrition
Autor: Nichols, B.L. (Children's Nutrition Research Center, Houston, TX) ; Carrazza, F ; Nichols, V.N ; Putman, M ; Johnston, P ; Rodrigues, M ; Quaroni, A ; Shiner, M
Assuntos: alpha-Glucosidases - analysis ; AMINOPEPTIDASA ; AMINOPEPTIDASE ; Aminopeptidases - analysis ; ATROFIA ; ATROPHIE ; BEBES ; BETA GALACTOSIDASA ; BETA GALACTOSIDASE ; Biological and medical sciences ; CD13 Antigens ; Chronic Disease ; DIARREA ; Diarrhea, Infantile - enzymology ; Diarrhea, Infantile - pathology ; DIARRHEE ; ENFANT EN BAS AGE ; Female ; FRUCTOFURANOSIDASA ; FRUCTOFURANOSIDASE ; Gastroenterology & Hepatology ; Gastroenterology. Liver. Pancreas. Abdomen ; GLUCOSIDASA ; GLUCOSIDASE ; Humans ; Infant ; Intestinal Mucosa - enzymology ; Intestinal Mucosa - pathology ; Jejunum - metabolism ; Jejunum - ultrastructure ; Life Sciences & Biomedicine ; Male ; MALNUTRICION ; MALNUTRITION ; Medical sciences ; Microscopy, Fluorescence ; Microvilli - enzymology ; Nutrition & Dietetics ; Nutrition Disorders - enzymology ; Nutrition Disorders - pathology ; Oligo-1,6-Glucosidase - analysis ; Pediatrics ; Science & Technology ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Sucrase - analysis
É parte de: Journal of pediatric gastroenterology and nutrition, 1992-05, Vol.14 (4), p.371-379
Notas: S30
9187694
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: The chronic diarrhea observed in young malnourished infants that is sensitive to dietary glucose and other carbohydrates is associated with variable degrees of patchy mucosal villous atrophy. To explore intrinsic mucosal function in the pathogenesis of this alimentary intolerance, we have conducted an immunohistologic investigation of brush-border enzyme proteins of clinically obtained, mucosal biopsy samples. We used a group of monoclonal antibodies against human brush-border aminopeptidase, sucrase/isomaltase (SI), maltase, and lactase enzyme proteins. SI was strongly and uniformly expressed in crypts and villi of 11 of the 14 subjects; in 3 subjects, however, SI was expressed in a mosaic pattern. Maltase and lactase were occasionally absent, but more commonly were expressed in a mosaic distribution. The mosaic expression of brush-border enzyme proteins has been reported in congenital enzyme deficiencies associated with normal intestinal histology. We report the mosaic expression of brush-border enzyme proteins as a functional alteration associated with a pathological lesion of the mucosa in infants with chronic diarrhea. Our observation challenges the existing concept of ontogenic regulation of brush-border enzyme activity
Editor: PHILADELPHIA: Lippincott-Raven Publishers
Idioma: Inglês

Links

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Mosaic expression of brush-border enzymes in infants with chronic diarrhea and malnutrition

Nichols, B.L. (Children's Nutrition Research Center, Houston, TX) ; Carrazza, F ; Nichols, V.N ; Putman, M ; Johnston, P ; Rodrigues, M ; Quaroni, A ; Shiner, M

PHILADELPHIA: Lippincott-Raven Publishers

Buscando em bases de dados remotas. Favor aguardar.