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Ankyrin Repeat-Rich Membrane Spanning/Kidins220 Protein Interacts with Mammalian Septin 5

Park, H.J., Seoul National University, Seoul, Republic of Korea ; Park, H.W., Seoul National University, Seoul, Republic of Korea ; Lee, S.J., Seoul National University, Seoul, Republic of Korea ; Arevalo, Juan Carlos, University of Salamanca, Salamanca, Spain ; Park, Y.S., Seoul National University, Seoul, Republic of Korea ; Lee, S.P., Seoul National University, Seoul, Republic of Korea ; Paik, K.S., Seoul National University, Seoul, Republic of Korea ; Chao, Moses V., New York University School of Medicine, New York, USA ; Chang, M.S., Seoul National University, Seoul, Republic of Korea

Molecules and Cells, 2010, 30(2), , pp.143-148 [Periódico revisado por pares]

Springer: Korean Society for Molecular and Cellular Biology

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Título:
Ankyrin Repeat-Rich Membrane Spanning/Kidins220 Protein Interacts with Mammalian Septin 5
Autor: Park, H.J., Seoul National University, Seoul, Republic of Korea ; Park, H.W., Seoul National University, Seoul, Republic of Korea ; Lee, S.J., Seoul National University, Seoul, Republic of Korea ; Arevalo, Juan Carlos, University of Salamanca, Salamanca, Spain ; Park, Y.S., Seoul National University, Seoul, Republic of Korea ; Lee, S.P., Seoul National University, Seoul, Republic of Korea ; Paik, K.S., Seoul National University, Seoul, Republic of Korea ; Chao, Moses V., New York University School of Medicine, New York, USA ; Chang, M.S., Seoul National University, Seoul, Republic of Korea
Assuntos: Actins - metabolism ; adaptor protein ; Amino Acid Sequence ; Animals ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Biotechnology ; Cell Biology ; Cell Cycle Proteins - chemistry ; Cell Cycle Proteins - metabolism ; Gene Deletion ; HEK293 Cells ; Hippocampus - cytology ; Humans ; Immunoprecipitation ; Life Sciences ; Membrane Proteins - chemistry ; Membrane Proteins - metabolism ; Mice ; Molecular Sequence Data ; Nerve Growth Factor - pharmacology ; Neurites - drug effects ; Neurites - metabolism ; Neurons - drug effects ; Neurons - metabolism ; neurotrophin ; PC12 Cells ; Phosphoproteins - chemistry ; Phosphoproteins - metabolism ; Protein Binding - drug effects ; Protein Interaction Mapping ; Protein Transport - drug effects ; Rats ; Rats, Sprague-Dawley ; RECEPTEURS ; RECEPTOR ; septin ; Septins - chemistry ; Septins - metabolism ; signal transduction ; 생물학
É parte de: Molecules and Cells, 2010, 30(2), , pp.143-148
Notas: 2011002217
A50
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
KISTI1.1003/JNL.JAKO201035356346747
G704-000079.2010.30.2.004
Descrição: Neurotrophin receptors utilize specific adaptor proteins to activate signaling pathways involved in various neuronal functions, such as neurite outgrowth and cytoskeletal remodeling. The Ankyrin-Repeat Rich Membrane Spanning (ARMS)/kinase D-interacting substrate-220 kDa (Kidins220) serves as a unique downstream adaptor protein of Trk receptor tyrosine kinases. To gain insight into the role of ARMS/Kidins220, a yeast two-hybrid screen of a rat dorsal root ganglion library was performed using the C-terminal region of ARMS/Kidins220 as bait. The screen identified a mammalian septin, Septin 5 (Sept5), as an interacting protein. Co-immunoprecipitation using lysates from transiently transfected HEK-293 cells revealed the specific interaction between ARMS/Kidins220 and Sept5. Endogenous ARMS/Kidins220 and Sept5 proteins were colocalized in primary hippocampal neurons and were also predominantly expressed at the plasma membrane and in the tips of growing neurites in nerve growth factor-treated PC12 cells. Mapping of Sept5 domains important for ARMS/Kidins220 binding revealed a highly conserved N-terminal region of Sept5. The direct interaction between ARMS/Kidins220 and Sept5 suggests a possible role of ARMS/Kidins220 as a functional link between neurotrophin receptors and septins to mediate neurotrophin-induced intracellular signaling events, such as neurite outgrowth and cytoskeletal remodeling.
Editor: Springer: Korean Society for Molecular and Cellular Biology
Idioma: Inglês;Coreano

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Ankyrin Repeat-Rich Membrane Spanning/Kidins220 Protein Interacts with Mammalian Septin 5

Springer: Korean Society for Molecular and Cellular Biology

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