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Synthesis and DNA Interaction of Platinum Complex/Peptide Chimera as Potential Drug Candidates (Eur. J. Org. Chem. 32/2010)

Damian, Mariana S. ; Hedman, Hanna K. ; Elmroth, Sofi K. C. ; Diederichsen, Ulf

European journal of organic chemistry, 2010-11, Vol.2010 (32), p.n/a [Periódico revisado por pares]

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Título:
Synthesis and DNA Interaction of Platinum Complex/Peptide Chimera as Potential Drug Candidates (Eur. J. Org. Chem. 32/2010)
Autor: Damian, Mariana S. ; Hedman, Hanna K. ; Elmroth, Sofi K. C. ; Diederichsen, Ulf
É parte de: European journal of organic chemistry, 2010-11, Vol.2010 (32), p.n/a
Notas: ark:/67375/WNG-6LFXHPVH-L
ArticleID:EJOC201090088
istex:BD0659B0AA2F3F68AA3E8B6A13F4CA23BFE41D08
Descrição: The cover picture shows the covalent DNA binding of cisplatin‐like complexes. These molecules were designed as hybrids between the platinum coordination site and positively charged peptides, which involves the covalent binding of one or two nucleobases by cisplatin‐analogous platinum complexes and the bending of double‐stranded DNA initiated by the peptide chain. An optimization of cisplatin‐like anticancer drugs is intended. Binding of cisplatin analogs is facilitated by simultaneous DNA bending. Details are discussed in the article by U. Diederichsen et al. on p. 6161 ff.
Editor: Weinheim: WILEY-VCH Verlag
Idioma: Inglês

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