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CD‐g‐CS nanoparticles for enhanced antibiotic treatment of Staphylococcus xylosus infection

Zheng, Si‐Di ; Zhang, Zhi‐Yun ; Ma, Jin‐Xin ; Qu, Qian‐Wei ; God'spowe, Bello‐Onaghise ; Qin, Yue ; Chen, Xue‐Ying ; Li, LU ; Zhou, Dong‐Fang ; Ding, Wen‐Ya ; Li, Yan‐Hua

Microbial biotechnology, 2022-02, Vol.15 (2), p.535-547 [Periódico revisado por pares]

United States: John Wiley & Sons, Inc

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Título:
CD‐g‐CS nanoparticles for enhanced antibiotic treatment of Staphylococcus xylosus infection
Autor: Zheng, Si‐Di ; Zhang, Zhi‐Yun ; Ma, Jin‐Xin ; Qu, Qian‐Wei ; God'spowe, Bello‐Onaghise ; Qin, Yue ; Chen, Xue‐Ying ; Li, LU ; Zhou, Dong‐Fang ; Ding, Wen‐Ya ; Li, Yan‐Hua
Assuntos: Animal models ; Animals ; Anti-Bacterial Agents - pharmacology ; Anti-Bacterial Agents - therapeutic use ; Antibiotics ; Antiinfectives and antibacterials ; Aqueous solutions ; Bacteria ; Bacterial infections ; Biofilms ; Cattle ; Chitosan ; Cyclodextrin ; Cyclodextrins ; Drug delivery systems ; Drug dosages ; Female ; Humans ; Hypotheses ; Infections ; Internalization ; Mastitis ; Mastitis - drug therapy ; Mice ; Nanoparticles ; NMR ; Nuclear magnetic resonance ; Particle size ; Staphylococcal Infections - drug therapy ; Staphylococcal Infections - microbiology ; Staphylococcus ; Staphylococcus xylosus
É parte de: Microbial biotechnology, 2022-02, Vol.15 (2), p.535-547
Notas: These two authors contributed equally.
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Descrição: Summary Staphylococcus xylosus (S. xylosus)‐induced cow mastitis is an extremely serious clinical problem. However, antibiotic therapy does not successfully treat S. xylosus infection because these bacteria possess a strong biofilm formation ability, which significantly reduces the efficacy of antibiotic treatments. In this study, we developed ceftiofur‐loaded chitosan grafted with β‐cyclodextrins (CD‐g‐CS) nanoparticles (CT‐NPs) using host–guest interaction. These positively charged nanoparticles improved bacterial internalization, thereby significantly improving the effectiveness of antibacterial treatments for planktonic S. xylosus. Moreover, CT‐NPs effectively inhibited biofilm formation and eradicated mature biofilms. After mammary injection in a murine model of S. xylosus‐induced mastitis, CT‐NPs significantly reduced bacterial burden and alleviated inflammation, thereby achieving optimized therapeutic efficiency for S. xylosus infection. In conclusion, this treatment strategy could improve the efficiency of antibiotic therapeutics and shows great potential in the treatment of S. xylosus infections. An efficient antibiotic nanoplatform against S. xylosus‐induced mastitis was developed by host‐guest interaction. The formed CT‐NPs were more effective than CTS at killing planktonic S. xylosus, effectively inhibiting biofilm formation and eliminating mature biofilms in vitro. Exhilaratingly, CT‐NPs also enhanced the therapeutic efficacy of treatments for S. xylosus infection when administered at low dosages in vivo, which proved very useful for treating S. xylosus in cases of mastitis.
Editor: United States: John Wiley & Sons, Inc
Idioma: Inglês

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CD‐g‐CS nanoparticles for enhanced antibiotic treatment of Staphylococcus xylosus infection

Zheng, Si‐Di ; Zhang, Zhi‐Yun ; Ma, Jin‐Xin ; Qu, Qian‐Wei ; God'spowe, Bello‐Onaghise ; Qin, Yue ; Chen, Xue‐Ying ; Li, LU ; Zhou, Dong‐Fang ; Ding, Wen‐Ya ; Li, Yan‐Hua

United States: John Wiley & Sons, Inc

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